{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["NIGMS"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA730049"],"scientific_name":["Homo sapiens"],"long_description":["Multiple independent sequence variants of the hTERT locus have been associated with telomere length and cancer risks in genome-wide association studies. Here, we identified an intronic variable number tandem repeat, VNTR2-1, as an enhancer-like element, which activated hTERT transcription in a cell and chromatin-dependent manner. VNTR2-1, consisting of 42-bp repeats with an array of E-boxes, cooperated with the proximal promoter in hTERT regulation by bHLH transcription factors and maintained hTERT expression during embryonic stem cell differentiation. Genomic deletion of VNTR2-1 in MelJuSo melanoma cells markedly reduced hTERT transcription, leading to telomere shortening, cellular senescence, and impairment of xenograft tumor growth. Interestingly, VNTR2-1 lengths varied widely in... (for more see dbGaP study page.)"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Repression of hTERT gene during cell differentiation","description":"Repression of hTERT gene during cell differentiation","dates":{"last_updated":"2025-09-24","first_public":"2021-05-28"},"accession":"PRJNA730049","cross_references":{"taxon":["9606"]}}