{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/042/SRR14646342/SRR14646342_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/093/SRR14646393/SRR14646393_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/015/SRR14646415/SRR14646415_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/052/SRR14646352/SRR14646352_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/038/SRR14646338/SRR14646338_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/037/SRR14646337/SRR14646337_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/089/SRR14646389/SRR14646389_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/001/SRR14646301/SRR14646301_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/000/SRR14646300/SRR14646300_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/078/SRR14646378/SRR14646378_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/048/SRR14646348/SRR14646348_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/094/SRR14646394/SRR14646394_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/007/SRR14646307/SRR14646307_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/031/SRR14646331/SRR14646331_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/079/SRR14646379/SRR14646379_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/049/SRR14646349/SRR14646349_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/063/SRR14646363/SRR14646363_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/059/SRR14646359/SRR14646359_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/071/SRR14646371/SRR14646371_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/076/SRR14646276/SRR14646276_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/072/SRR14646372/SRR14646372_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/075/SRR14646275/SRR14646275_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/000/SRR14646400/SRR14646400_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/014/SRR14646414/SRR14646414_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/074/SRR14646374/SRR14646374_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/027/SRR14646327/SRR14646327_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/057/SRR14646357/SRR14646357_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/056/SRR14646356/SRR14646356_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/026/SRR14646326/SRR14646326_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/041/SRR14646341/SRR14646341_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/012/SRR14646312/SRR14646312_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/011/SRR14646311/SRR14646311_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/029/SRR14646329/SRR14646329_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/085/SRR14646385/SRR14646385_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/046/SRR14646346/SRR14646346_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/004/SRR14646304/SRR14646304_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/097/SRR14646297/SRR14646297_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/091/SRR14646391/SRR14646391_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/017/SRR14646417/SRR14646417_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/034/SRR14646334/SRR14646334_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/007/SRR14646407/SRR14646407_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/075/SRR14646375/SRR14646375_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/022/SRR14646422/SRR14646422_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/019/SRR14646419/SRR14646419_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/090/SRR14646390/SRR14646390_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/087/SRR14646387/SRR14646387_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/019/SRR14646319/SRR14646319_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/069/SRR14646269/SRR14646269_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/022/SRR14646422/SRR14646422_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/099/SRR14646299/SRR14646299_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/073/SRR14646273/SRR14646273_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/076/SRR14646376/SRR14646376_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/061/SRR14646361/SRR14646361_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/010/SRR14646410/SRR14646410_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/064/SRR14646364/SRR14646364_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/067/SRR14646367/SRR14646367_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/016/SRR14646316/SRR14646316_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/055/SRR14646355/SRR14646355_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/019/SRR14646319/SRR14646319_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/034/SRR14646334/SRR14646334_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/022/SRR14646322/SRR14646322_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/004/SRR14646304/SRR14646304_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/064/SRR14646364/SRR14646364_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/082/SRR14646382/SRR14646382_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/001/SRR14646401/SRR14646401_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/070/SRR14646370/SRR14646370_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/079/SRR14646279/SRR14646279_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/094/SRR14646294/SRR14646294_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/064/SRR14646264/SRR14646264_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/067/SRR14646267/SRR14646267_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/097/SRR14646397/SRR14646397_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/076/SRR14646276/SRR14646276_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/026/SRR14646326/SRR14646326_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/013/SRR14646413/SRR14646413_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/081/SRR14646381/SRR14646381_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/070/SRR14646270/SRR14646270_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/003/SRR14646403/SRR14646403_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/012/SRR14646312/SRR14646312_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/066/SRR14646266/SRR14646266_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/065/SRR14646265/SRR14646265_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/094/SRR14646294/SRR14646294_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/079/SRR14646279/SRR14646279_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/066/SRR14646366/SRR14646366_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/036/SRR14646336/SRR14646336_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/002/SRR14646302/SRR14646302_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/042/SRR14646342/SRR14646342_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/051/SRR14646351/SRR14646351_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/007/SRR14646407/SRR14646407_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/011/SRR14646411/SRR14646411_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/096/SRR14646296/SRR14646296_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/075/SRR14646375/SRR14646375_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/072/SRR14646272/SRR14646272_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/064/SRR14646264/SRR14646264_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/099/SRR14646399/SRR14646399_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/012/SRR14646412/SRR14646412_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/074/SRR14646274/SRR14646274_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/002/SRR14646402/SRR14646402_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/018/SRR14646418/SRR14646418_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/069/SRR14646369/SRR14646369_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/050/SRR14646350/SRR14646350_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/062/SRR14646362/SRR14646362_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/068/SRR14646268/SRR14646268_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/059/SRR14646359/SRR14646359_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/006/SRR14646406/SRR14646406_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/047/SRR14646347/SRR14646347_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/035/SRR14646335/SRR14646335_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/029/SRR14646329/SRR14646329_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/023/SRR14646323/SRR14646323_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/072/SRR14646372/SRR14646372_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/005/SRR14646305/SRR14646305_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/098/SRR14646298/SRR14646298_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/071/SRR14646271/SRR14646271_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/096/SRR14646396/SRR14646396_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/021/SRR14646321/SRR14646321_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/084/SRR14646384/SRR14646384_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/090/SRR14646390/SRR14646390_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/017/SRR14646317/SRR14646317_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/011/SRR14646311/SRR14646311_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/033/SRR14646333/SRR14646333_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/095/SRR14646295/SRR14646295_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/045/SRR14646345/SRR14646345_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/060/SRR14646360/SRR14646360_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/057/SRR14646357/SRR14646357_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/032/SRR14646332/SRR14646332_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/089/SRR14646389/SRR14646389_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/039/SRR14646339/SRR14646339_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/020/SRR14646320/SRR14646320_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/008/SRR14646308/SRR14646308_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/077/SRR14646377/SRR14646377_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/030/SRR14646330/SRR14646330_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/018/SRR14646318/SRR14646318_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/068/SRR14646368/SRR14646368_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/027/SRR14646327/SRR14646327_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/065/SRR14646365/SRR14646365_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/015/SRR14646315/SRR14646315_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/056/SRR14646356/SRR14646356_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/053/SRR14646353/SRR14646353_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/044/SRR14646344/SRR14646344_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/003/SRR14646303/SRR14646303_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/041/SRR14646341/SRR14646341_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/006/SRR14646306/SRR14646306_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/071/SRR14646371/SRR14646371_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/080/SRR14646380/SRR14646380_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/074/SRR14646374/SRR14646374_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/086/SRR14646386/SRR14646386_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/083/SRR14646383/SRR14646383_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/095/SRR14646395/SRR14646395_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/092/SRR14646392/SRR14646392_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/098/SRR14646398/SRR14646398_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/078/SRR14646278/SRR14646278_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/065/SRR14646365/SRR14646365_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/014/SRR14646314/SRR14646314_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/024/SRR14646324/SRR14646324_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/077/SRR14646277/SRR14646277_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/066/SRR14646366/SRR14646366_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/009/SRR14646309/SRR14646309_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/080/SRR14646380/SRR14646380_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/093/SRR14646293/SRR14646293_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/025/SRR14646325/SRR14646325_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/096/SRR14646396/SRR14646396_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/067/SRR14646267/SRR14646267_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/013/SRR14646313/SRR14646313_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/092/SRR14646292/SRR14646292_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/070/SRR14646370/SRR14646370_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/054/SRR14646354/SRR14646354_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/002/SRR14646402/SRR14646402_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/001/SRR14646401/SRR14646401_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/055/SRR14646355/SRR14646355_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/002/SRR14646302/SRR14646302_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/036/SRR14646336/SRR14646336_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/087/SRR14646387/SRR14646387_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/085/SRR14646385/SRR14646385_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/066/SRR14646266/SRR14646266_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/081/SRR14646381/SRR14646381_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/095/SRR14646395/SRR14646395_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/009/SRR14646409/SRR14646409_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/099/SRR14646299/SRR14646299_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/063/SRR14646263/SRR14646263_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/097/SRR14646297/SRR14646297_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/020/SRR14646420/SRR14646420_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/033/SRR14646333/SRR14646333_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/008/SRR14646408/SRR14646408_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/005/SRR14646305/SRR14646305_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/050/SRR14646350/SRR14646350_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/051/SRR14646351/SRR14646351_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/021/SRR14646421/SRR14646421_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/032/SRR14646332/SRR14646332_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/003/SRR14646303/SRR14646303_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/035/SRR14646335/SRR14646335_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/073/SRR14646373/SRR14646373_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/022/SRR14646322/SRR14646322_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/099/SRR14646399/SRR14646399_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/005/SRR14646405/SRR14646405_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/061/SRR14646361/SRR14646361_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/016/SRR14646316/SRR14646316_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/010/SRR14646410/SRR14646410_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/063/SRR14646363/SRR14646363_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/028/SRR14646328/SRR14646328_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/010/SRR14646310/SRR14646310_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/016/SRR14646416/SRR14646416_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/075/SRR14646275/SRR14646275_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/088/SRR14646388/SRR14646388_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/058/SRR14646358/SRR14646358_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/073/SRR14646373/SRR14646373_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/052/SRR14646352/SRR14646352_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/019/SRR14646419/SRR14646419_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/040/SRR14646340/SRR14646340_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/028/SRR14646328/SRR14646328_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/079/SRR14646379/SRR14646379_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/010/SRR14646310/SRR14646310_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/031/SRR14646331/SRR14646331_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/016/SRR14646416/SRR14646416_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/013/SRR14646413/SRR14646413_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/046/SRR14646346/SRR14646346_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/043/SRR14646343/SRR14646343_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/007/SRR14646307/SRR14646307_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/058/SRR14646358/SRR14646358_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/076/SRR14646376/SRR14646376_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/088/SRR14646388/SRR14646388_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/094/SRR14646394/SRR14646394_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/091/SRR14646391/SRR14646391_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/073/SRR14646273/SRR14646273_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/070/SRR14646270/SRR14646270_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/009/SRR14646409/SRR14646409_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/030/SRR14646330/SRR14646330_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/054/SRR14646354/SRR14646354_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/053/SRR14646353/SRR14646353_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/025/SRR14646325/SRR14646325_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/013/SRR14646313/SRR14646313_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/078/SRR14646378/SRR14646378_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/077/SRR14646377/SRR14646377_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/049/SRR14646349/SRR14646349_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/040/SRR14646340/SRR14646340_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/093/SRR14646293/SRR14646293_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/001/SRR14646301/SRR14646301_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/043/SRR14646343/SRR14646343_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/092/SRR14646392/SRR14646392_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/037/SRR14646337/SRR14646337_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/063/SRR14646263/SRR14646263_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/014/SRR14646414/SRR14646414_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/067/SRR14646367/SRR14646367_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/082/SRR14646382/SRR14646382_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/020/SRR14646420/SRR14646420_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/060/SRR14646360/SRR14646360_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/097/SRR14646397/SRR14646397_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/048/SRR14646348/SRR14646348_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/047/SRR14646347/SRR14646347_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/078/SRR14646278/SRR14646278_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/069/SRR14646369/SRR14646369_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/093/SRR14646393/SRR14646393_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/084/SRR14646384/SRR14646384_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/083/SRR14646383/SRR14646383_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/009/SRR14646309/SRR14646309_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/062/SRR14646362/SRR14646362_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/039/SRR14646339/SRR14646339_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/068/SRR14646368/SRR14646368_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/044/SRR14646344/SRR14646344_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/045/SRR14646345/SRR14646345_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/017/SRR14646317/SRR14646317_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/000/SRR14646300/SRR14646300_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/008/SRR14646308/SRR14646308_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/038/SRR14646338/SRR14646338_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/015/SRR14646315/SRR14646315_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/014/SRR14646314/SRR14646314_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/024/SRR14646324/SRR14646324_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/023/SRR14646323/SRR14646323_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/021/SRR14646321/SRR14646321_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/020/SRR14646320/SRR14646320_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/021/SRR14646421/SRR14646421_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/018/SRR14646318/SRR14646318_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/072/SRR14646272/SRR14646272_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/006/SRR14646306/SRR14646306_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/098/SRR14646298/SRR14646298_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/098/SRR14646398/SRR14646398_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/086/SRR14646386/SRR14646386_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/096/SRR14646296/SRR14646296_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/069/SRR14646269/SRR14646269_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/008/SRR14646408/SRR14646408_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/005/SRR14646405/SRR14646405_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/017/SRR14646417/SRR14646417_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/011/SRR14646411/SRR14646411_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/092/SRR14646292/SRR14646292_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/068/SRR14646268/SRR14646268_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/015/SRR14646415/SRR14646415_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/003/SRR14646403/SRR14646403_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/006/SRR14646406/SRR14646406_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/095/SRR14646295/SRR14646295_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/012/SRR14646412/SRR14646412_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/018/SRR14646418/SRR14646418_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/000/SRR14646400/SRR14646400_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/065/SRR14646265/SRR14646265_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/074/SRR14646274/SRR14646274_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/077/SRR14646277/SRR14646277_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR146/071/SRR14646271/SRR14646271_2.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Harvard"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA732700"],"scientific_name":["Homo sapiens"],"long_description":["Replicative senescence (RS) as a model has become the central focus of research into cellular aging in vitro. Despite decades of study, this process through which cells cease dividing is not fully understood in culture, and even much less so in vivo during development and with aging. Here, we revisit Hayflick’s original observation of RS in WI-38 human fetal lung fibroblasts equipped with a battery of high dimensional modern techniques and analytical methods to deeply profile the process of RS across each aspect of the central dogma and beyond. We applied and integrated RNA-seq, proteomics, metabolomics, and ATAC-seq to a high resolution RS time course. We found that the transcriptional changes that underlie RS manifest early, gradually increase, and correspond to a concomitant global increase in accessibility in nucleolar and lamin associated domains. During RS WI-38 fibroblast gene expression patterns acquire a striking resemblance to those of myofibroblasts in a process similar to the epithelial to mesenchymal transition (EMT). This observation is supported at the transcriptional, proteomic, and metabolomic levels of cellular biology. In addition, we provide evidence suggesting that t s conversion is regulated by the transcription factors YAP1/TEAD1 and the signaling molecule TGF-β Overall design: WI-38 cells were grown and sampled during approach to replicative senescence for use in RNA-seq, scRNA-seq and ATAC-seq. Samples were matched with hTERT immortalized counterparts. Further controls for slowed growth (cell density) and DNA damage (radiation-RIS) were included for bulk RNA-seq."],"tag":["xref:PubMed:35119359"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites, and Chromatin","description":"Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites, and Chromatin","dates":{"last_updated":"2025-09-24","first_public":"2021-05-28"},"accession":"PRJNA732700","cross_references":{"GEO":["GSE175533"],"taxon":["9606"],"PubMed":["35119359"]}}