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Oncology of Solid Tumors, Experimental and Clinical Research Center, Charité University Medicine"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA749570"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:34670579"],"long_description":["14 PDX models of pmCRC were established, including 9 matched PD3D/PDX models, and treatment response to 17 SoC and targeted therapies was monitored, which resulted in drug-dependent inter- and intra-patient specific growth inhibition. Analysis of the molecular data of the models and patient tissue resulted in the identification of predictive biomarkers for treatment with 5-FU, irinotecan, trametinib, erlotinib, cetuximab and avastin, oxaliplatin, selumetinib, docetaxel and everolimus. Conclusions: The establishment of a preclinical drug testing platform based on in vitro and in vivo matched pmCRC models, molecularly characterized by multi-omics technology, facilitated the identification of predictive biomarkers for treatment response, as well as cancer relevant signatures for effective therapies, ready for validation in clinical cohorts. Overall design: Transcriptomic analysis of pmCRC patient metastases (n=13), corresponding PDX tumors (n=14) and matching PD3D cell culture models (n=8)."],"repository":["ENA"],"name_synonyms":["Colorectal Tumors, Carcinomas, large bowel cancer, tumor cell migration, Colorectal Neoplasm, Carcinoma, Colorectal Cancer, Metastasis, Neoplasms, Metastases, susceptibility to, Colorectal Carcinoma, metastasis, Colorectal Carcinomas, Neoplasm Metastases, Cancers, neoplasm metastasis, Tumor, Colorectal Tumor, cancer of large bowel, autosomal dominant, large intestine cancer, cancer metastasis, cancer of the large intestine, Metastase, Colorectal, colorectal cancer, colon cancer, Neoplasm, cancer of the large bowel, CRC, Colorectal Cancers, cancer of large intestine, colorectal (colon or rectal) cancer., tumor metastasis, somatic mutation, Tumors, Cancer"],"description_synonyms":["Colorectal Tumors, Carcinomas, large bowel cancer, tumor cell migration, Colorectal Neoplasm, Carcinoma, Colorectal Cancer, Metastasis, Neoplasms, Metastases, susceptibility to, Colorectal Carcinoma, metastasis, Colorectal Carcinomas, Neoplasm Metastases, Cancers, neoplasm metastasis, Tumor, Colorectal Tumor, cancer of large bowel, autosomal dominant, large intestine cancer, cancer metastasis, cancer of the large intestine, Metastase, Colorectal, colorectal cancer, colon cancer, Neoplasm, cancer of the large bowel, CRC, Colorectal Cancers, cancer of large intestine, colorectal (colon or rectal) cancer., tumor metastasis, somatic mutation, Tumors, Cancer"],"additional_accession":[]},"is_claimable":false,"name":"Peritoneal metastasis of colorectal cancer (pmCRC): Identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models","description":"Peritoneal metastasis of colorectal cancer (pmCRC): Identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models","dates":{"last_updated":"2025-09-24","first_public":"2021-10-29"},"accession":"PRJNA749570","cross_references":{"GEO":["GSE180790"],"taxon":["9606"],"PubMed":["34670579"]}}