ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/055/SRR15242555/SRR15242555.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/061/SRR15242561/SRR15242561.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/058/SRR15242558/SRR15242558.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/050/SRR15242550/SRR15242550.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/049/SRR15242549/SRR15242549.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/047/SRR15242547/SRR15242547.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/052/SRR15242552/SRR15242552.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/057/SRR15242557/SRR15242557.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/053/SRR15242553/SRR15242553.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/046/SRR15242546/SRR15242546.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/059/SRR15242559/SRR15242559.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/051/SRR15242551/SRR15242551.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/054/SRR15242554/SRR15242554.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/048/SRR15242548/SRR15242548.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/060/SRR15242560/SRR15242560.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR152/056/SRR15242556/SRR15242556.fastq.gzprimaryOK200GenomicsCutaneous Leukocyte Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseaseshttps://www.ebi.ac.uk/ena/browser/view/PRJNA749587Mus musculusxref:PubMed:34582748Inflammation triggered by viral infections can obscure tissue function. We utilized a model of systemic anti-viral immunity and found that the ADAM10-Notch signaling axis in type I/III interferon-responsive upper hair follicles (HF) was crucial for the expression of genes that regulated skin microbiota and protected HFs and its stem cell niche from inflammatory destruction. Overall design: Transcriptomic changes in sorted YFP+ upper HF cells from ROSA26YFP_Mx1 and ADAM10 ROSA26YFP_Mx1mice 4 days after poly(I:C) induction.ENAGS11410, GH05739, LcpIII, IFI78, Mx-1, Follicles, BG:DS07660.3, 1700031C13Rik, e(Pc), l(2)br38, A4, AD18, l(2)34Da, CG7147, br38, L[[3]]CP3, AD10, TYPE, AI893580, LGMD2C, Hair, DAGA4, DmelCG7147, l34Da, III, GH14582, 34Da, ADAM10, MX, madm, ad10, Kuz, 3, l(2)c00136, kuzbanian, MAM, LCP3, SCG3, Hair Follicles, IFI-78K, DmelCG2043, l(2)03782, xadam10, DmelCG7776, lcp3, folliculus pili, HsT18717, DMDA1, DMLCP3, Mx, l(2)28-28-12, LCP-3, kuz, anon-35Fa, MxA, CD156c, DmelCG5861, DMDA, CP3, l(2)k01403, Follicle, anon-35Fc, MADM., E(PC), DmelLcp3, anon-48Ac, BG:DS02740.11, SCARMD2, CT22079, CG7776, CG2043, Interferon, 11410, cd156c, RAKGS11410, GH05739, LcpIII, IFI78, Mx-1, Follicles, BG:DS07660.3, 1700031C13Rik, e(Pc), l(2)br38, A4, AD18, l(2)34Da, CG7147, br38, L[[3]]CP3, AD10, TYPE, AI893580, LGMD2C, Hair, DAGA4, DmelCG7147, l34Da, III, GH14582, 34Da, ADAM10, MX, madm, ad10, Kuz, 3, l(2)c00136, kuzbanian, MAM, LCP3, SCG3, Hair Follicles, IFI-78K, DmelCG2043, l(2)03782, xadam10, DmelCG7776, lcp3, folliculus pili, HsT18717, DMDA1, DMLCP3, Mx, l(2)28-28-12, LCP-3, kuz, anon-35Fa, MxA, CD156c, DmelCG5861, DMDA, CP3, l(2)k01403, Follicle, anon-35Fc, MADM., E(PC), DmelLcp3, anon-48Ac, BG:DS02740.11, SCARMD2, CT22079, CG7776, CG2043, Interferon, 11410, cd156c, RAKfalseTranscriptomic profiles of type I/III interferon-responsive hair follicle subsets from ROSA26YFP_Mx1 and ADAM10 ROSA26YFP_Mx1miceTranscriptomic profiles of type I/III interferon-responsive hair follicle subsets from ROSA26YFP_Mx1 and ADAM10 ROSA26YFP_Mx1mice2025-09-242021-07-27PRJNA749587GSE1807981009034582748