ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR153/012/SRR15326612/SRR15326612.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR153/016/SRR15326616/SRR15326616.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR153/015/SRR15326615/SRR15326615.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR153/019/SRR15326619/SRR15326619.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR153/021/SRR15326621/SRR15326621.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR153/020/SRR15326620/SRR15326620.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR153/017/SRR15326617/SRR15326617.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR153/010/SRR15326610/SRR15326610.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR153/018/SRR15326618/SRR15326618.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR153/014/SRR15326614/SRR15326614.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR153/011/SRR15326611/SRR15326611.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR153/013/SRR15326613/SRR15326613.fastq.gzprimaryOK200GenomicsHealth Science Center, Shenzhen Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA751581Znic finger proteins play crucial roles in development and disease, including tumorigenesis. Here, we identifed ZNF280C as a novel oncogenic driver in colorectal cancer, and systematically studied the molecular mechanisms underlying ZNF280C-mediated malignant transformation and progression. Overall design: RKO colon cancer cells stably expressing a ZNF280C-targeting shRNA controlled by a tetracycline-inducible promoter were treated with or without 1 ug/ml doxycycline for 72 hours, and the cells were harvested for analysis as described below. For transgenic mice experiments, Zfp280c knock-out or wild-type C57BL/6J mice were sacrificed at 12 weeks of age and colon tissues were havested for transriptomic analysis as described below.xref:PubMed:35605119ENAAdenocarcinoma, colon tumor, 3.4.22.-, Colon Neoplasm, malignant neoplasm of colon, Suhw3, Laboratory, Feature, Colon Adenocarcinomas, malignant, Neoplasms, Mus domesticus, mouse, mini-ICE, Colon Cancer, CASP-14, RNA-seq., Zfp633, Colon Adenocarcinoma, Adenocarcinomas, autosomal dominant, House Mouse, Cell, colon neoplasm, malignant colonic neoplasm, Colonic Cancers, Characteristic, House, Mus, Mini-ICE, Neoplasm, Colon Neoplasms, Mus musculus domesticus, malignant tumor of colon, malignant colonic tumor, malignant tumour of colon, Whole Transcriptome Shotgun Sequencing, CRC, Mice, ZNF633, malignant tumor of the colon, malignant colon tumour, Mus musculus, Colon Cancers, Colonic, Caspase-14 subunit p10, Swiss, mice, susceptibility to, Znf280c, Colonic Neoplasm, Swiss Mouse, mKIAA1584, Colon cancer, House Mice, Swiss Mice, Colonic Cancer, Caspase-14 subunit p19, Cancers, Cancer of the Colon, Features, MICE, SUHW3, Colon, large intestine cancer, Laboratory Mice, domesticus, malignant colon tumor, malignant colonic tumour, colon cancer, Cancer of Colon, malignant tumour of the colon, malignant neoplasm of the colon, Mouse, Characteristics, cancer of colon, malignant colon neoplasm, BC028839, Laboratory Mouse, somatic mutation, CancerAdenocarcinoma, colon tumor, 3.4.22.-, Colon Neoplasm, malignant neoplasm of colon, Suhw3, Laboratory, Feature, Colon Adenocarcinomas, malignant, Neoplasms, Mus domesticus, mouse, mini-ICE, Colon Cancer, CASP-14, RNA-seq., Zfp633, Colon Adenocarcinoma, Adenocarcinomas, autosomal dominant, House Mouse, Cell, colon neoplasm, malignant colonic neoplasm, Colonic Cancers, Characteristic, House, Mus, Mini-ICE, Neoplasm, Colon Neoplasms, Mus musculus domesticus, malignant tumor of colon, malignant colonic tumor, malignant tumour of colon, Whole Transcriptome Shotgun Sequencing, CRC, Mice, ZNF633, malignant tumor of the colon, malignant colon tumour, Mus musculus, Colon Cancers, Colonic, Caspase-14 subunit p10, Swiss, mice, susceptibility to, Znf280c, Colonic Neoplasm, Swiss Mouse, mKIAA1584, Colon cancer, House Mice, Swiss Mice, Colonic Cancer, Caspase-14 subunit p19, Cancers, Cancer of the Colon, Features, MICE, SUHW3, Colon, large intestine cancer, Laboratory Mice, domesticus, malignant colon tumor, malignant colonic tumour, colon cancer, Cancer of Colon, malignant tumour of the colon, malignant neoplasm of the colon, Mouse, Characteristics, cancer of colon, malignant colon neoplasm, BC028839, Laboratory Mouse, somatic mutation, CancerfalseEpigenomic and transcriptomic features induced by silencing of ZNF280C in colon cancer cells and knock-out of Zfp280c in mice [RNA-Seq]Epigenomic and transcriptomic features induced by silencing of ZNF280C in colon cancer cells and knock-out of Zfp280c in mice [RNA-Seq]2025-09-242022-05-22PRJNA751581GSE18132735605119