ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/015/SRR15404515/SRR15404515_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/017/SRR15404517/SRR15404517_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/021/SRR15404521/SRR15404521_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/019/SRR15404519/SRR15404519_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/020/SRR15404520/SRR15404520_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/016/SRR15404516/SRR15404516_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/018/SRR15404518/SRR15404518_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/019/SRR15404519/SRR15404519_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/014/SRR15404514/SRR15404514_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/020/SRR15404520/SRR15404520_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/016/SRR15404516/SRR15404516_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/018/SRR15404518/SRR15404518_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/015/SRR15404515/SRR15404515_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/017/SRR15404517/SRR15404517_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/021/SRR15404521/SRR15404521_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR154/014/SRR15404514/SRR15404514_2.fastq.gzprimaryOK200GenomicsKey Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, sun yat sen universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA753487Homo sapiensxref:PubMed:34555354We identified an oncomicropeptide that was enriched on ribosomes and regulated translation. We further performed the ribosome profiling and RNA-seq libraries sequenced to globally identify the mRNAs that the peptie targeted. Interestingly, the ribo-seq data has shown that a large number of mRNAs were significantly downregulated in the peptide-knockdown samples. Finally, we discovered that high expression of the peptide supported a specific translation program to facilitate cancer progression. Overall design: Sh-NC and sh-Speptide MOLM-13 cells usedENAfalseAn oncomicropeptide Regulates translation in leukemiaAn oncomicropeptide Regulates translation in leukemia2025-09-242021-08-14PRJNA753487GSE181795960634555354