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Sciences, The University of California Riverside</center_name><full_dataset_link>https://www.ebi.ac.uk/ena/browser/view/PRJNA755611</full_dataset_link><scientific_name>Mus musculus</scientific_name><long_description>Purpose: To elucidate how SARS-CoV-2 spike protein affects macrophage inflammatory responses Methods: Peritoneal macrophages were isolated from Myeloid-specific IKKβ knockout mice (IKKβΔMye) and control littermates (IKKβ F/F). Then the macrophages were treated with lentivirus expressing Spike protein for 24 hours Results: Deficiency of IKKβ nearly abolished spike protein-associated geneset scores and DEGs-associated key inflammatory pathways. Conclusions: These results indicate that SARS-CoV-2 Spike protein induces strong inflammatory responses in macrophages, potentially through activation of canonical IKKβ/NF-κB signaling Overall design: Macrophagic mRNA profiles of control and IKKβ-deficient macrophages after 24-hour treatment of Lentivirus expressing Spike protein</long_description><repository>ENA</repository></additional><is_claimable>false</is_claimable><name>The impact of Spike protein on macrophage inflammation</name><description>The impact of Spike protein on macrophage inflammation</description><dates><last_updated>2025-09-24</last_updated><first_public>2022-04-20</first_public></dates><accession>PRJNA755611</accession><cross_references><GEO>GSE182264</GEO><taxon>10090</taxon></cross_references></HashMap>