{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR156/096/SRR15613996/SRR15613996.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR156/095/SRR15613995/SRR15613995.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR156/093/SRR15613993/SRR15613993.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR156/094/SRR15613994/SRR15613994.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA757776"],"long_description":["Treatment with actinomycin D and nutlin-3a strongly activates p53 tumor suppressor protein and regulates expression of its target genes. CHIR-98014 is an inhibitor of GSK3 kinase but it probably inhibits other kinases. The goal of the project was to find candidate p53 target genes and the genes whose expression is modulated by CHIR-98014."],"tag":["xref:EuropePMC:PMC11274236","xref:EuropePMC:PMC8538697"],"repository":["ENA"],"description_synonyms":["Therapy, Actinomycin, Transcriptome, Transcriptome Profile, ActD, Expression Profiles, Gene Expression Profile, Gene, 13)oxatetra-azacyclohexadecin-10-yl)-4, LyovacCosmegen, Profiles, Cosmegen, actinomycin IV, 10, 11, whole transcriptome, Gene Expression, Cosmegen., Expression Signatures, Gene Expression Signatures, 4, Gene Expression Signature, 5, Cosmegen Lyovac, N'-bis(hexadecahydro-2, 7, 14-pentaoxo-1H-pyrrolo(2, Expression Profile, actinomycin C1, Transcriptome Profiles, treatment, 1-i)(1, 13-bis(1-methylethyl)-1, Lyovac-Cosmegen, Profile, 2-amino-N, 6-dimethyl-3-oxo-3H-phenoxazine-1, 9-dicarboxamide, Signatures, Treatments, Actinomycin D, Therapeutic, Expression Signature, Gene Expression Profiles, Dactinomycin, Lyovac Cosmegen, disease management, Transcriptomes, Therapies, Treatment, Meractinomycin, Signature, 9-trimethyl-6, Lyovac"],"additional_accession":[]},"is_claimable":false,"name":"","description":"Transcriptome changes following treatment with actinomycin D and nutlin-3a and/or CHIR-98014","dates":{"last_updated":"2023-05-17","first_public":"2021-08-27"},"accession":"PRJNA757776","cross_references":{}}