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and Post Genomic Unit, IRCCS Mondino Foundationhttps://www.ebi.ac.uk/ena/browser/view/PRJNA759611Homo sapiensAmyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease caused by loss of motor neurons. SOD1 may have a toxic role in the pathogenesis of ALS when the protein aggregates in the cytoplasm increased accumulation of soluble nuclear SOD1 (nSOD1) represents a protective cellular reaction. Overall design: Peripheral Blood Mononuclear Cells derived from 18 sALS patients and 12 age- and sex-matched healthy controls (CTRL) were deep-sequenced and included in Real Time PCR experiments.ENALou Gehrig disease, ATHSP70, Ribonucleic, DmelCG5610, Gehrigs Disease, l(3)L3929, Hsp70, Amyotrophic Lateral Sclerosis, Hsc-4, scd, heat shock protein 70, motor neuron disease, HSP70, APG-2, Hsp110, Non Polyadenylated, Lou Gehrig's disease, RNA Gene Products, Gehrig Disease, irp94, DmelCG6489, DmelCG18743, ALS (Amyotrophic Lateral Sclerosis), hsp70 Ba, Cu/Zn-SOD, Motor neuron disease, RY, Lou-Gehrigs, DmelCG5834, hsc4, HSPH2, xhsp70, Guam Form of Amyotrophic Lateral Sclerosis, HS24/P52, alpha-like, DmelCG31359, Lateral Scleroses, Hsp70Bc, Hsp70Bb, hsp70 Aa, Hsp70Bd, GRP78, Amyotrophic lateral sclerosis, DmelCG31366, CG4264, hsc70, homodimer, Bulbar motor neuron disease, Hsp70b, Hsp70a, dALS, ribose nucleic acid, dHsp70, amyotrophic lateral sclerosis, CG5610-PA, ribonucleic acids, Parkinsonism/Dementia complex of Guam, HS24|P52, HSP70Bbb, Hsp70B, Lou Gehrig's Disease, Hsp70A, Dm-hsp70, Ribonukleinsaeure, pentosenucleic acids, CG5610, Ribonucleic acids, ARABIDOPSIS HEAT SHOCK PROTEIN 70, HSC4, Hsc4, Acid, DmelCG4264, Motor Neuron Disease, Acr96A, Gehrig's Disease, Lou-Gehrigs Disease, Hsp70-BC, Hsp70-Ab, ALS - Amyotrophic lateral sclerosis, nAcr96Aa, Amyotrophic, hsp-70, Patient, MOTOR NEURON DIS AMYOTROPHIC LATERAL SCLEROSIS, Hsp70A7d, dhsp70, CRS4, HSC70-4, CG6489, CG31449, Amyotrophic Lateral Sclerosis With Dementia, Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1, CG5834, l(3)j7A4, Dalpha1, Ipo1, Sclerosis, hs70, hsp70(87A), hsp70Ab, Cu|Zn-SOD, hsp70Aa, HEL-S-5a, homodimer., IPOA, bs17d06.y1, 87A, Hsp70-1, bulbar, hsp70RY, DMHSP7A2, Gene Products, hsp70Ba, hsp70Bc, hsp70Bb, Hsp-c4, hsp70Bb-prime, LOU GEHRIGS DIS, dhsc70, alpha1, Acr96Aa, DMHSP7D1, BAP74, Hsp 70, CuZnSOD, GEHRIGS DIS, CG31359, hsp70 87A, Hsc70, hsp70 87C, CG31354, Non-Polyadenylated RNA, SOD, Clients, HSC70, anon-WO0118547.237, Hsp-70Aa, Hsc4p, Lou Gehrig Disease, CG31366, Amyotrophic lateral sclerosis (disorder), RNA, Disease, ALS, Guam Form, mKIAA4111, Ipo-1, RNS, Client, Hsp70ab, Lou Gehrigs Disease, B430204E11Rik, hsp70A, HSC-70, hsp70B, E(csp)1545, ALs, hsp68, als, hsc70-4, yeast nucleic acid, Amyotrophic Lateral, hsp70, ALS1, Hsp70(87C), nAcRs, CG18743, Hsp70.1, ribonucleic acid, Albs, hsp70a, LOU GEHRIG DIS, dhsp70Aa, hsp70b, l(3)03550, Sod-1, Dementia With Amyotrophic Lateral Sclerosis, AcrB, Non Polyadenylated RNA, E(nd)195, i190, hSod1, AMYOTROPHIC SCLEROSIS, Non-Polyadenylated, nAChR, Ribonucleic Acid, DmHSP70AA, HEL-S-44, hsp 70, SOD1, DmelCG31449, Charcot disease, Hsp70Bbc, HSP70Bc, Hsp70aB, SODCLou Gehrig disease, ATHSP70, Ribonucleic, DmelCG5610, Gehrigs Disease, l(3)L3929, Hsp70, Amyotrophic Lateral Sclerosis, Hsc-4, scd, heat shock protein 70, motor neuron disease, HSP70, APG-2, Hsp110, Non Polyadenylated, Lou Gehrig's disease, RNA Gene Products, Gehrig Disease, irp94, DmelCG6489, DmelCG18743, ALS (Amyotrophic Lateral Sclerosis), hsp70 Ba, Cu/Zn-SOD, Motor neuron disease, RY, Lou-Gehrigs, DmelCG5834, hsc4, HSPH2, xhsp70, Guam Form of Amyotrophic Lateral Sclerosis, HS24/P52, alpha-like, DmelCG31359, Lateral Scleroses, Hsp70Bc, Hsp70Bb, hsp70 Aa, Hsp70Bd, GRP78, Amyotrophic lateral sclerosis, DmelCG31366, CG4264, hsc70, homodimer, Bulbar motor neuron disease, Hsp70b, Hsp70a, dALS, ribose nucleic acid, dHsp70, amyotrophic lateral sclerosis, CG5610-PA, ribonucleic acids, Parkinsonism/Dementia complex of Guam, HS24|P52, HSP70Bbb, Hsp70B, Lou Gehrig's Disease, Hsp70A, Dm-hsp70, Ribonukleinsaeure, pentosenucleic acids, CG5610, Ribonucleic acids, ARABIDOPSIS HEAT SHOCK PROTEIN 70, HSC4, Hsc4, Acid, DmelCG4264, Motor Neuron Disease, Acr96A, Gehrig's Disease, Lou-Gehrigs Disease, Hsp70-BC, Hsp70-Ab, ALS - Amyotrophic lateral sclerosis, nAcr96Aa, Amyotrophic, hsp-70, Patient, MOTOR NEURON DIS AMYOTROPHIC LATERAL SCLEROSIS, Hsp70A7d, dhsp70, CRS4, HSC70-4, CG6489, CG31449, Amyotrophic Lateral Sclerosis With Dementia, Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1, CG5834, l(3)j7A4, Dalpha1, Ipo1, Sclerosis, hs70, hsp70(87A), hsp70Ab, Cu|Zn-SOD, hsp70Aa, HEL-S-5a, homodimer., IPOA, bs17d06.y1, 87A, Hsp70-1, bulbar, hsp70RY, DMHSP7A2, Gene Products, hsp70Ba, hsp70Bc, hsp70Bb, Hsp-c4, hsp70Bb-prime, LOU GEHRIGS DIS, dhsc70, alpha1, Acr96Aa, DMHSP7D1, BAP74, Hsp 70, CuZnSOD, GEHRIGS DIS, CG31359, hsp70 87A, Hsc70, hsp70 87C, CG31354, Non-Polyadenylated RNA, SOD, Clients, HSC70, anon-WO0118547.237, Hsp-70Aa, Hsc4p, Lou Gehrig Disease, CG31366, Amyotrophic lateral sclerosis (disorder), RNA, Disease, ALS, Guam Form, mKIAA4111, Ipo-1, RNS, Client, Hsp70ab, Lou Gehrigs Disease, B430204E11Rik, hsp70A, HSC-70, hsp70B, E(csp)1545, ALs, hsp68, als, hsc70-4, yeast nucleic acid, Amyotrophic Lateral, hsp70, ALS1, Hsp70(87C), nAcRs, CG18743, Hsp70.1, ribonucleic acid, Albs, hsp70a, LOU GEHRIG DIS, dhsp70Aa, hsp70b, l(3)03550, Sod-1, Dementia With Amyotrophic Lateral Sclerosis, AcrB, Non Polyadenylated RNA, E(nd)195, i190, hSod1, AMYOTROPHIC SCLEROSIS, Non-Polyadenylated, nAChR, Ribonucleic Acid, DmHSP70AA, HEL-S-44, hsp 70, SOD1, DmelCG31449, Charcot disease, Hsp70Bbc, HSP70Bc, Hsp70aB, SODCfalseRNA molecular signature profiling in PBMCs of sporadic ALS patients: HSP70 overexpression is associated with nuclear SOD1RNA molecular signature profiling in PBMCs of sporadic ALS patients: HSP70 overexpression is associated with nuclear SOD12025-09-242022-01-28PRJNA759611GSE1832049606