{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR157/030/SRR15712430/SRR15712430.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR157/027/SRR15712427/SRR15712427.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR157/028/SRR15712428/SRR15712428.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR157/029/SRR15712429/SRR15712429.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR157/031/SRR15712431/SRR15712431.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR157/024/SRR15712424/SRR15712424.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR157/026/SRR15712426/SRR15712426.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR157/025/SRR15712425/SRR15712425.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Hideo Watanabe, Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA760446"],"scientific_name":["Mus musculus"],"long_description":["Molecular classification of small cell lung cancer (SCLC), a lethal and heterogeneous disease, was recently proposed based on expression of four lineage-defining transcription factors SCLC-A (ASCL1), SCLC-N (NEUROD1), SCLC-Y (YAP1), and SCLC-P (POU2F3). In this study, unsupervised clustering of genome-wide histone H3K27 acetylation profiles uncovered previously unappreciated epigenomic heterogeneity of this recalcitrant disease. Specifically, the major SCLC-A subtype, which accounts for approximately 70% of all SCLC cases, was subdivided into two new subtypes SCLC-A1 and SCLC-A2. SCLC-A1 is distinguished by the presence of super-enhancer at the NKX2-1 locus, also observed in a murine SCLC model and human SCLC specimens. We found NKX2-1, a master regulator of lung lineages as well as a critical lineage factor in central nervous system, is uniquely functionally relevant in SCLC-A1, where it maintains neural lineage rather than pulmonary epithelial identity. Through integrative proteomic, transcriptomic and cistromic analyses, we found that maintenance of this neural identity in SCLC-A1 is mediated by collaborative transcriptional activity with another neuronal transcriptional factor SOX1 Overall design: Transcriptomic profile of 4 RP and 4 RPN tumors"],"tag":["xref:PubMed:35848993"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional circuitry of NKX2-1 and SOX1 defines a previously unrecognized lineage subtype of small cell lung cancer to maintain neuroendocrine differentiation (RNA-Seq Mouse)","description":"Transcriptional circuitry of NKX2-1 and SOX1 defines a previously unrecognized lineage subtype of small cell lung cancer to maintain neuroendocrine differentiation (RNA-Seq Mouse)","dates":{"last_updated":"2025-09-24","first_public":"2022-10-07"},"accession":"PRJNA760446","cross_references":{"GEO":["GSE183371"],"taxon":["10090"],"PubMed":["35848993"]}}