ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR159/058/SRR15913358/SRR15913358_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR159/061/SRR15913361/SRR15913361_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR159/058/SRR15913358/SRR15913358_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR159/059/SRR15913359/SRR15913359_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR159/060/SRR15913360/SRR15913360_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR159/061/SRR15913361/SRR15913361_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR159/057/SRR15913357/SRR15913357_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR159/062/SRR15913362/SRR15913362_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR159/057/SRR15913357/SRR15913357_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR159/062/SRR15913362/SRR15913362_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR159/059/SRR15913359/SRR15913359_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR159/060/SRR15913360/SRR15913360_2.fastq.gzprimaryOK200GenomicsHuazhong Agricultural Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA763827Mus musculusOur current study overexpressed Vdbp stably in DC to explore the function of this gene. CKK-8 results revealed Vdbp successfully inhibited viability of DC. Besides, we found overexpressing this gene greatly promoted apoptosis and obviously altered cell cycle distribution in DC. Moreover, RNA sequencing (RNA-seq) was carried out and numerous differently expressed genes (DEGs) were obtained. The results indicated that Vdbp globally mediated expression of mRNAs, which might translate into its potential functions. Finally, bio-informatics analysis illustrated that most DEGs were more uniformly enriched in immunity-related pathways. We believe that Vdbp regulates the function of DC by altering its cellular immunity. Overall design: Examination the overexpression of Vdbp in DCs.ENAfalseTranscriptomic Analysis Reveals the Responses of Dendritic Cells to VdbpTranscriptomic Analysis Reveals the Responses of Dendritic Cells to Vdbp2025-09-242024-08-02PRJNA763827GSE18425810090