{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Fritz Lipmann Institute"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA768439"],"long_description":["Aging has been defined as a progressive decline in physiological function over time. This study identifies genes associated with the aging process that are present in nematodes, killifish, zebrafish, and mice in an evolutionary conserved manner. Out of 45 genes identified in our comparative approach, we find that impairing the las1l/Y6B3B.9 gene, which encodes for a ribosomal biogenesis factor, results in the most pronounced extension of Caenorhabditis elegans lifespan. Impairment of las1l/Y6B3B.9 reduces 60S ribosomes subunit expression and impairs protein synthesis. In addition, we discover a novel role of las1l/Y6B3B.9 in regulating histone marks and transcription, revealing responsibility of the tyrosine phosphatase Y39A3A.4 and its target, NUCL-1, for las1l/Y6B3B.9- mediated lifespan extension, providing pharmacological targets for fine-tuning of the translational machinery in higher organisms, to ultimately promote healthspan."],"repository":["ENA"],"description_synonyms":["HITS-CLIP, High Throughput Sequencing of RNA Isolated by Crosslinking Immunoprecipitation, post-transcriptional gene silencing by RNA, par1, RNA, ChIP-Chip, Par1c, CG8201, Chromatin Immuno-precipitation, Cross Linking and Immunoprecipitation Followed by Deep Sequencing, Par-1c, posttranscriptional gene silencing by siRNA, dPAR1, ChIP Sequencing, dPar1, dMARK, 1810030A06Rik, CLIP-Seq, Assay for Transposase-Accessible Chromatin Using Sequencing, cosuppression, ChIP-PET, DmelCG8201, CG11960, ChIP-Exo, CG30131, CG30132, EMK, RNAi, Interference, dPAR-1, anon-WO0210402.19, DPAR-1, Chromatin Immunoprecipitation Sequencing-Chip, Post Transcriptional, High-Throughput Sequencing of RNA Isolated by Crosslinking Immunoprecipitation, dPar-1, RNA Silencing, Silencing, ChIA-PET, Post-Transcriptional Gene, Post-Transcriptional Gene Silencings, Chromatin Immunoprecipitation Sequencing Chip, 27C1, Chromatin Immuno precipitation Sequencing, ChIP, Posttranscriptional, Chromatin Immunoprecipitation Paired End Tag, l(2)k06323, Posttranscriptional Gene Silencing, Chromatin Immuno Precipitation Paired End Tag, Cross-Linking and Immunoprecipitation Followed by Deep Sequencing, Chromatin Immunoprecipitation, Chromatin Immuno-precipitation Sequencing, ChIP Exonuclease, Co Suppression, quelling, ChIP-Seq, Cosuppression, Sequencing, Assay for Transposase Accessible Chromatin Using Sequencing, dJ475B7.2, Chromatin Immunoprecipitation Paired-End Tag, PAR-1, Gene Silencings, l(2)27C1, Post-Transcriptional, Post Transcriptional Gene Silencing., Gene Silencing, 5830482G23Rik, Las1-like, BcDNA:RH48823, Chromatin Immuno-Precipitation Paired-End Tag, MARK, ATAC-Seq, Chromatin Immunoprecipitation Sequencing-Chips, Par-1, DPar1, PAR1, Par1, Co-Suppression, Post-Transcriptional Gene Silencing, ChIP-Exonuclease, CG16701"],"additional_accession":[]},"is_claimable":false,"name":"","description":"ChIP sequencing of H3K27ac mark of C.elegans treat with las1l /Y6B3B.9 RNAi","dates":{"last_updated":"2024-07-24","first_public":"2024-05-11"},"accession":"PRJNA768439","cross_references":{}}