ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/093/SRR16578393/SRR16578393_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/002/SRR16578402/SRR16578402_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/097/SRR16578397/SRR16578397_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/091/SRR16578391/SRR16578391_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/094/SRR16578394/SRR16578394_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/095/SRR16578395/SRR16578395_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/001/SRR16578401/SRR16578401_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/000/SRR16578400/SRR16578400_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/001/SRR16578401/SRR16578401_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/005/SRR16578405/SRR16578405_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/004/SRR16578404/SRR16578404_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/007/SRR16578407/SRR16578407_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/006/SRR16578406/SRR16578406_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/098/SRR16578398/SRR16578398_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/099/SRR16578399/SRR16578399_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/089/SRR16578389/SRR16578389_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/095/SRR16578395/SRR16578395_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/096/SRR16578396/SRR16578396_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/093/SRR16578393/SRR16578393_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/092/SRR16578392/SRR16578392_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/090/SRR16578390/SRR16578390_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/091/SRR16578391/SRR16578391_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/007/SRR16578407/SRR16578407_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/004/SRR16578404/SRR16578404_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/003/SRR16578403/SRR16578403_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/099/SRR16578399/SRR16578399_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/097/SRR16578397/SRR16578397_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/089/SRR16578389/SRR16578389_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/092/SRR16578392/SRR16578392_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/088/SRR16578388/SRR16578388_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/090/SRR16578390/SRR16578390_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/094/SRR16578394/SRR16578394_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/098/SRR16578398/SRR16578398_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/096/SRR16578396/SRR16578396_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/088/SRR16578388/SRR16578388_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/005/SRR16578405/SRR16578405_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/006/SRR16578406/SRR16578406_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/003/SRR16578403/SRR16578403_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/002/SRR16578402/SRR16578402_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR165/000/SRR16578400/SRR16578400_2.fastq.gzprimaryOK200GenomicsCepko, Genetics, Harvard Medical Schoolhttps://www.ebi.ac.uk/ena/browser/view/PRJNA774789Mus musculusCone photoreceptors in retina degeneration mouse models degenerate from the center to the periphery. However, the far peripheral cones survive long-term. We found that retinoic acid signaling is both necessary and sufficient for cone survival. Overall design: Bulk RNA-seq of CAR+ cones and Muller glia was performed on P30 central and peripheral retinas. Briefly, the central one-third and peripheral one-third retinal tissues were dissected out from 3 mice. The tissue was dissociated into single cells and labeled with anti-CAR antibody. The CAR+ central and peripheral cells were FACS-isolated, and the RNA was extracted.ENAfalseRetinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degenerationRetinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration2025-09-242021-12-19PRJNA774789GSE18661210090