{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR173/094/SRR17312494/SRR17312494.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR173/093/SRR17312493/SRR17312493.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Department of Immunology, The University of Tokyo"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA791669"],"scientific_name":["Mus musculus"],"tag":["xref:PubMed:35999397","xref:PubMed:35999392"],"long_description":["The destruction of bone and cartilage results in a loss of joint functionality, critically impairing the quality of life in arthritis patients. Synovial fibroblasts (SFs) critically contribute to the pathogenesis of rheumatoid arthritis (RA) by acquiring either a pro-inflammatory or tissue-destructive phenotype. To explore the molecular mechanisms underlying the pathogenic fibroblast phenotype in arthritis, we performed single-cell RNA sequencing (scRNA-seq) on the synovial cells which were isolated from collagen-induced arthritis (CIA) mice. Overall design: scRNA-seq analysis was performed on synovial cells which were isolated from the knee joints of CIA mice (n=3) and healthy control mice (n=9). Alignment, quantitation and aggregation of the sample count matrices (CIA + control) were performed using the 10x Genomics Cell Ranger pipeline (v.3.0) according to the manufacturer’s protocol (GENEWIZ)."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic analysis of synovial cells derived from collagen-induced arthritis mice","description":"Transcriptomic analysis of synovial cells derived from collagen-induced arthritis mice","dates":{"last_updated":"2025-09-24","first_public":"2022-07-08"},"accession":"PRJNA791669","cross_references":{"GEO":["GSE192504"],"taxon":["10090"],"PubMed":["35999397","35999392"]}}