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Hedgehog signaling was required to prevent premature differentiation and disruption of cardiac morphogenesis in vivo and the Hedgehog signaling transcription factor GLI1 was sufficient to delay differentiation in stem cell-derived cardiac progenitors in vitro. GLI1 directly activated a de novo progenitor-specific network in vitro that inhibited the induction of the cardiac differentiation program. The GLI1-driven gene regulatory network is sufficient to induce Hedgehog-naive in vitro cardiac progenitors to adopt an epigenomic state reminiscent of second heart field cardiac progenitors in vivo. A Hh-dependent GLI transcription factor switch functions as a differentiation timer, restricting activity of the progenitor network to the second heart field and permitting cardiomyocyte differentiation in the heart. GLI1 expression is broadly associated with the progenitor state, and its activity also delayed the differentiation of specified neural progenitors in vitro. We posit that Hedgehog signaling functions as a heterochronic regulator that transiently maintains diverse progenitor populations for complex organ development and that may explain diverse Hedgehog signaling-dependent phenomena. Overall design: Transcriptomic and epigenomic analyses of Hedgehog/GLI dependent-networks in cardiac and neural progenitors"],"repository":["ENA"],"name_synonyms":["Networks, HITS-CLIP, High Throughput Sequencing of RNA Isolated by Crosslinking Immunoprecipitation, xshh, Controlling, biological signaling, ChIP-Chip, Modules, Gene Regulatory, Erinaceidae, Chromatin Immuno-precipitation, Cross Linking and Immunoprecipitation Followed by Deep Sequencing, ChIP Sequencing, Gene, CLIP-Seq, Network, Assay for Transposase-Accessible Chromatin Using Sequencing, ChIP-PET, Gene Circuits, ChIP-Exo, Circuit, Transcriptional Networks, Chromatin Immunoprecipitation Sequencing-Chip, Hedgehog, Transcriptional Network, hedgehog, Gene Regulatory Network, High-Throughput Sequencing of RNA Isolated by Crosslinking Immunoprecipitation, Module, Transcriptional, Chromatin Immunoprecipitation Sequencing Chip, Regulatory Network, Circuits, Chromatin Immuno precipitation Sequencing, Gene Circuit, reference sample, Gene Module, ChIP, Chromatin Immunoprecipitation Paired End Tag, Chromatin Immuno Precipitation Paired End Tag, Cross-Linking and Immunoprecipitation Followed by Deep Sequencing, Chromatin Immunoprecipitation, Chromatin Immuno-precipitation Sequencing, ChIP Exonuclease, Xhh, ChIP-Seq, Sequencing, signalling, Assay for Transposase Accessible Chromatin Using Sequencing, Chromatin Immunoprecipitation Paired-End Tag, signalling process, Gene Modules, Regulatory Networks, ChIA-PET., signaling process, Gene Networks, Chromatin Immuno-Precipitation Paired-End Tag, Gene Network, ATAC-Seq, Chromatin Immunoprecipitation Sequencing-Chips, ChIP-Exonuclease, single organism signaling, Controlled"],"description_synonyms":["Networks, HITS-CLIP, High Throughput Sequencing of RNA Isolated by Crosslinking Immunoprecipitation, xshh, Controlling, biological signaling, ChIP-Chip, Modules, Gene Regulatory, Erinaceidae, Chromatin Immuno-precipitation, Cross Linking and Immunoprecipitation Followed by Deep Sequencing, ChIP Sequencing, Gene, CLIP-Seq, Network, Assay for Transposase-Accessible Chromatin Using Sequencing, ChIP-PET, Gene Circuits, ChIP-Exo, Circuit, Transcriptional Networks, Chromatin Immunoprecipitation Sequencing-Chip, Hedgehog, Transcriptional Network, hedgehog, Gene Regulatory Network, High-Throughput Sequencing of RNA Isolated by Crosslinking Immunoprecipitation, Module, Transcriptional, Chromatin Immunoprecipitation Sequencing Chip, Regulatory Network, Circuits, Chromatin Immuno precipitation Sequencing, Gene Circuit, reference sample, Gene Module, ChIP, Chromatin Immunoprecipitation Paired End Tag, Chromatin Immuno Precipitation Paired End Tag, Cross-Linking and Immunoprecipitation Followed by Deep Sequencing, Chromatin Immunoprecipitation, Chromatin Immuno-precipitation Sequencing, ChIP Exonuclease, Xhh, ChIP-Seq, Sequencing, signalling, Assay for Transposase Accessible Chromatin Using Sequencing, Chromatin Immunoprecipitation Paired-End Tag, signalling process, Gene Modules, Regulatory Networks, ChIA-PET., signaling process, Gene Networks, Chromatin Immuno-Precipitation Paired-End Tag, Gene Network, ATAC-Seq, Chromatin Immunoprecipitation Sequencing-Chips, ChIP-Exonuclease, single organism signaling, Controlled"],"additional_accession":[]},"is_claimable":false,"name":"Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages (ChIP-Seq)","description":"Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages (ChIP-Seq)","dates":{"last_updated":"2025-09-24","first_public":"2022-10-07"},"accession":"PRJNA803232","cross_references":{"GEO":["GSE196083"],"taxon":["10090"],"PubMed":["36108627"]}}