{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR184/077/SRR18461177/SRR18461177_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR184/075/SRR18461175/SRR18461175_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR184/076/SRR18461176/SRR18461176_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR184/074/SRR18461174/SRR18461174_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR184/075/SRR18461175/SRR18461175_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR184/076/SRR18461176/SRR18461176_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR184/077/SRR18461177/SRR18461177_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR184/074/SRR18461174/SRR18461174_2.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["wuhan university"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA819277"],"scientific_name":["Mus musculus"],"long_description":["Chronic myeloid leukemia (CML) is a myeloproliferative disorder derived from hematopoietic stem cells (HSCs) that harbor Philadelphia chromosome (Ph chromosome). Leukemia stem cells (LSCs) in CML are insensitive to TKIs treatment, and are responsible for disease relapse. However, the molecular mechanisms for LSCs survival remains elusive. Here we show that YBX1 plays an important role in regulating survival of CML LSCs. We find that YBX1 expression is significantly increased in CML cells. Using CML patient-derived cell lines and a BCR-ABL-induced CML mouse model, we confirm that YBX1 is required for survival maintenance of LSCs. Deletion of YBX1 impairs the propagation of CML through impairing cell cycle and inducing apoptosis of LSCs. Mechanistically, we find that YBX1 regulates expression of apoptosis-related genes, and YBX1 binds MYC and BCL2 transcripts. YBX1 loss decreases expression of MYC and BCL2 by accelerating their mRNA decay. In addition, restoration of MYC and BCL2 efficiently rescue the defects of YBX1-deficient CML cells. Overall, our findings reveal a critical role of YBX1 in maintaining survival of CML LSCs, which may provide a rationale for targeting YBX1 in CML treatment. Overall design: RNAseq of WT and YBX1cKO LSCs"],"repository":["ENA"],"description_synonyms":["Myelogenous Leukemias, Myelocytic, Chronic Myelocytic Leukemia, Chronic Granulocytic Leukemia, single-organism developmental process, Philadelphia Positive, Chronic Myeloid Leukemia, Myeloid, Colony-Forming Units, postnatal development, Progenitor Cell, Myelocytic Leukemia, growth and development, chronic granulocytic leukaemia, NSEP-1, Philadelphia-Positive Myeloid Leukemias, CML, chronic myelogenous, Yb1, Dbpb, leukaemia NOS, Mother Cells, CSDA2, Ph1 Positive, atypical, Philadelphia-Positive Myeloid Leukemia, Leucocythaemia, leukaemia, MSY1, Msy1, Progenitor, Chronic Myelocytic Leukemias, mYB-1a, Chronic Granulocytic Leukemias, YB-1, chronic myeloid, Leukemia, YB1, Granulocytic Leukemia, Chronic Myelogenous Leukemias, Leucocythemias, Mother, Myelogenous Leukemia, Granulocytic, Nsep1, Cbfa, BP-8, Ph1-Positive Myelogenous Leukemias, time of survival, Myeloid Leukemia, Myelocytic Leukemias, NSEP1, Ph1-Positive Myeloid Leukemia, Chronic, leukemia, Myelogenous, Colony Forming Unit, Granulocytic Leukemias, Chronic Myelocytic, Progenitor Cells, Ph1-Positive Myelogenous Leukemia, Philadelphia-Positive, Leukemias, Cell, chronic, development, Ph1-Positive, Ph1-Positive Myeloid Leukemias, MDR-NF1, 1700102N10Rik, survival, Colony-Forming Unit, Chronic myelogenous leukemia, Stem Cell, chronic myelogenous leukemia, Philadelphia-Positive Myeloid, Myeloid Leukemias, EF1A, Leucocythaemias, Mother Cell, Chronic granulocytic leukemia, Leucocythemia, Chronic Granulocytic, Chronic Myelogenous, Chronic Myelogenous Leukemia, death rate, Chronic Myeloid Leukemias, C79409, Stem, postnatal growth, Ph1-Positive Myelogenous, Colony Forming Units, Ph1-Positive Myeloid, Byb1, chronic granulocytic leukemia, Ph1-Positive Myeloid., chronic myelogenous leukaemia, Cells, CML - chronic Myelogenous Leukemia, DBPB, chronic myeloid leukaemia, CSDB, Ef1a, growth, dbpB, Chronic Myeloid"],"name_synonyms":["Myelogenous Leukemias, Myelocytic, Chronic Myelocytic Leukemia, Chronic Granulocytic Leukemia, single-organism developmental process, Philadelphia Positive, Chronic Myeloid Leukemia, Myeloid, Colony-Forming Units, postnatal development, Progenitor Cell, Myelocytic Leukemia, growth and development, chronic granulocytic leukaemia, NSEP-1, Philadelphia-Positive Myeloid Leukemias, CML, chronic myelogenous, Yb1, Dbpb, leukaemia NOS, Mother Cells, CSDA2, Ph1 Positive, atypical, Philadelphia-Positive Myeloid Leukemia, Leucocythaemia, leukaemia, MSY1, Msy1, Progenitor, Chronic Myelocytic Leukemias, mYB-1a, Chronic Granulocytic Leukemias, YB-1, chronic myeloid, Leukemia, YB1, Granulocytic Leukemia, Chronic Myelogenous Leukemias, Leucocythemias, Mother, Myelogenous Leukemia, Granulocytic, Nsep1, Cbfa, BP-8, Ph1-Positive Myelogenous Leukemias, time of survival, Myeloid Leukemia, Myelocytic Leukemias, NSEP1, Ph1-Positive Myeloid Leukemia, Chronic, leukemia, Myelogenous, Colony Forming Unit, Granulocytic Leukemias, Chronic Myelocytic, Progenitor Cells, Ph1-Positive Myelogenous Leukemia, Philadelphia-Positive, Leukemias, Cell, chronic, development, Ph1-Positive, Ph1-Positive Myeloid Leukemias, MDR-NF1, 1700102N10Rik, survival, Colony-Forming Unit, Chronic myelogenous leukemia, Stem Cell, chronic myelogenous leukemia, Philadelphia-Positive Myeloid, Myeloid Leukemias, EF1A, Leucocythaemias, Mother Cell, Chronic granulocytic leukemia, Leucocythemia, Chronic Granulocytic, Chronic Myelogenous, Chronic Myelogenous Leukemia, death rate, Chronic Myeloid Leukemias, C79409, Stem, postnatal growth, Ph1-Positive Myelogenous, Colony Forming Units, Ph1-Positive Myeloid, Byb1, chronic granulocytic leukemia, Ph1-Positive Myeloid., chronic myelogenous leukaemia, Cells, CML - chronic Myelogenous Leukemia, DBPB, chronic myeloid leukaemia, CSDB, Ef1a, growth, dbpB, Chronic Myeloid"],"additional_accession":[]},"is_claimable":false,"name":"Ybx1 is required for Survival of Leukemia Stem Cells and the Development of Chronic Myeloid Leukemia","description":"Ybx1 is required for Survival of Leukemia Stem Cells and the Development of Chronic Myeloid Leukemia","dates":{"last_updated":"2025-09-24","first_public":"2022-03-30"},"accession":"PRJNA819277","cross_references":{"GEO":["GSE199304"],"taxon":["10090"]}}