ENAGenomicsCIBERhttps://www.ebi.ac.uk/ena/browser/view/PRJNA820029Mus musculusxref:PubMed:36499248We treated obese mice being fed a high-fat diet with exosomes transfected with a combination of inhibitors of obesity-associated miR-122 and miR-192 and a mimic of exercise-associated miR-133b. We used microarrays to detail the global changes of gene expression induced by the exosomal treatment in liver, adipose and muscle tissues in comparison with HIIT. Overall design: C57BL6/J male mice were rendered obese and glucose intolerant after being fed high-fat diet for 10 weeks. These mice were then randomly separated into three groups. One group was injected with transfected exosomes for 4 weeks (EXO). Another group underwent exercise training in parallel (HIIT), whereas a third group was left untreated (HFD). We also used a group of lean mice as controls (CT).ENA3.4.22.-, RNA, Cyp306a1, Laboratory, CYP306A1, stRNA, Mus domesticus, T3H13.3, CASP14, mouse, CG6578, Small Temporal RNA, obesity disease, mini-ICE, CASP-14, Primary, House Mouse, exo, Adiposis, obesity, Obesity, mXrn1, Small, Obese, unspecified, DmelCG6578, Micro RNA, Dhm2, House, Mus, Mini-ICE, Obesity [Ambiguous], Obese (finding), Mus musculus domesticus, OBESITY, pre-miRNA, Mice, obesity disorder, Mus musculus., Obesity (disorder), T3H13_3, pri miRNA, Mus musculus, miRNAs, Small Temporal, Caspase-14 subunit p10, Micro, 306a1, Temporal RNA, Swiss, mice, Obesity NOS, dysfunction, Having too much body fat, Swiss Mouse, Adiposity, Primary MicroRNA, House Mice, Swiss Mice, OBESITY NOS, Caspase-14 subunit p19, Overweight and obesity, pathophysiology, miRNA, Primary miRNA, MICE, pri-miRNA, Laboratory Mice, domesticus, MicroRNA, EXORDIUM, Mouse, Cyp306a1-Dm, pre miRNA, Laboratory Mouse3.4.22.-, RNA, Cyp306a1, Laboratory, CYP306A1, stRNA, Mus domesticus, T3H13.3, CASP14, mouse, CG6578, Small Temporal RNA, obesity disease, mini-ICE, CASP-14, Primary, House Mouse, exo, Adiposis, obesity, Obesity, mXrn1, Small, Obese, unspecified, DmelCG6578, Micro RNA, Dhm2, House, Mus, Mini-ICE, Obesity [Ambiguous], Obese (finding), Mus musculus domesticus, OBESITY, pre-miRNA, Mice, obesity disorder, Mus musculus., Obesity (disorder), T3H13_3, pri miRNA, Mus musculus, miRNAs, Small Temporal, Caspase-14 subunit p10, Micro, 306a1, Temporal RNA, Swiss, mice, Obesity NOS, dysfunction, Having too much body fat, Swiss Mouse, Adiposity, Primary MicroRNA, House Mice, Swiss Mice, OBESITY NOS, Caspase-14 subunit p19, Overweight and obesity, pathophysiology, miRNA, Primary miRNA, MICE, pri-miRNA, Laboratory Mice, domesticus, MicroRNA, EXORDIUM, Mouse, Cyp306a1-Dm, pre miRNA, Laboratory MousefalseComparison of the effects of HIIT and exo-miRNAs upon obesity-associated metabolic dysfunction in HFD mice.Comparison of the effects of HIIT and exo-miRNAs upon obesity-associated metabolic dysfunction in HFD mice.2025-09-242022-12-08PRJNA820029GSE1994651009036499248