ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/020/SRR18503120/SRR18503120_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/015/SRR18503115/SRR18503115_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/016/SRR18503116/SRR18503116_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/019/SRR18503119/SRR18503119_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/018/SRR18503118/SRR18503118_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/019/SRR18503119/SRR18503119_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/020/SRR18503120/SRR18503120_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/016/SRR18503116/SRR18503116_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/017/SRR18503117/SRR18503117_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/018/SRR18503118/SRR18503118_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/017/SRR18503117/SRR18503117_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/015/SRR18503115/SRR18503115_2.fastq.gzprimaryOK200GenomicsKunming Institute of Zoology, Chinese Academy of Scienceshttps://www.ebi.ac.uk/ena/browser/view/PRJNA820709Mus musculusThe goals of this study are to dmonstrate transcriptomic profiling of SARS-CoV-2 infected brain samples. Hippocampal mRNA profiles of hACE2 transgenic mice at 30-day post SARS-CoV-2 infection were generated by bulk RNA sequencing, in 3 samples each group. Sequence reads were mapped to the mouse genome (GRCm38) using STAR. RSEM was used to count aligned reads that mapped to the annotated mouse genes. Gene-level differential expression analyses were performed using R package DESeq2. Results showed that SARS-CoV-2 infection led to long-term effect regarding neuroinflammation and neuronal function. Overall design: Hippocampal mRNA profiles of three 30-day post SARS-CoV-2 infected hACE2 transgenic mice and three uninfected hACE2 transgenic micexref:PubMed:36180433ENAfalseTranscriptomic analysis of hippocampus of hACE2 mice with SARS-CoV-2 infectionTranscriptomic analysis of hippocampus of hACE2 mice with SARS-CoV-2 infection2025-09-242022-10-07PRJNA820709GSE1995451009036180433