ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/079/SRR18534479/SRR18534479.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/082/SRR18534482/SRR18534482.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/086/SRR18534486/SRR18534486_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/080/SRR18534480/SRR18534480_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/081/SRR18534481/SRR18534481_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/080/SRR18534480/SRR18534480.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/079/SRR18534479/SRR18534479_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/083/SRR18534483/SRR18534483.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/082/SRR18534482/SRR18534482_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/084/SRR18534484/SRR18534484_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/085/SRR18534485/SRR18534485_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/081/SRR18534481/SRR18534481_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/085/SRR18534485/SRR18534485.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/080/SRR18534480/SRR18534480_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/085/SRR18534485/SRR18534485_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/084/SRR18534484/SRR18534484_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/083/SRR18534483/SRR18534483_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/081/SRR18534481/SRR18534481.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/084/SRR18534484/SRR18534484.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/086/SRR18534486/SRR18534486_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/082/SRR18534482/SRR18534482_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/083/SRR18534483/SRR18534483_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/079/SRR18534479/SRR18534479_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR185/086/SRR18534486/SRR18534486.fastq.gzprimaryOK200GenomicsFaculty of Health Sciences, University of Macauhttps://www.ebi.ac.uk/ena/browser/view/PRJNA821462Homo sapiensTo investigate whether differential susceptibility exists between healthy and PAH patients to e-cig exposure and the molecular mechanisms, human iPSC lines from two healthy volunteers and two FPAH patients were first differentiated into ECs. iPSC-ECs were then treated with and without e-cigarette extract for 24 hours. Overall design: RNA-seq of iPSC-ECs with and without e-cigarette extract treatment over a period of 24 hours.ENAfalseE-cigarettes induce dysregulation of autophagy leading to endothelial dysfunction in pulmonary arterial hypertensionE-cigarettes induce dysregulation of autophagy leading to endothelial dysfunction in pulmonary arterial hypertension2025-09-242025-03-29PRJNA821462GSE1997649606