{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Institute of Hematology &Blood Disease Hospital,Chinese Academy of Medical Sciences"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA823376"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:37474525"],"long_description":["Here, we use single cell transcriptomics to characterize a dynamic senescence process of in vitro expanded MSC products from adipose tissue (AD), bone marrow (BM), placenta membrane (PM) and umbilical cord (UC). We found that cultured MSCs underwent progressive cell aging. As compared to perinatal MSCs (derived from PM and UC), adult MSCs (derived from AD and BM) showed higher degree of senescence and impaired immunosuppressive function. Moreover, we identified the transcriptional network regulating the intra-population functional diversity, which provides us guidance to drive reprogramming of determined MSCs lineage with specific cellular functions for a particular therapeutic intent. Overall design: We performed droplet-based scRNA-seq of over 40,000 cells to construct a molecular landscape and dissecting the heterogeneity of MSCs from perinatal and adult human tissues."],"repository":["ENA"],"description_synonyms":["Adipose, d230, determination, placenta (Spanish, dTAFII250, cyclic nucleotide-regulated small mechanosensitive ion channel, yolk stalk, fat, EfW1, Fat Pad, dmTAF[[II]]230, Membrane Tissues, exact), Fatty Tissue, dmTAF1, Taf230, integral component of membrane, Marrow, medulla ossea, Yellow, Umbilical Cords, Fatty, fatty tissue, placenta, fat tissue, TAF250, Taf200, Pads, dTAF[[II]]250, funiculus umbilicalis., TFIID TAF250, cel, cell, Tissues, membrane region, Tissue, Taf1p, Red Marrow, 胎座 (Japanese, dTAF250, portion of placenta tissue (exact), chorda umbilicalis, Normal, birth cord, Red, region of membrane, bodyfat, Pad, TAF, eutherian placenta, Membrane Tissue, membrane, dTAF[[II]]230, TAF[[II]]250, placentas (exact, Fat Pads, plural), Placentas, Cords, TAF200, integral to membrane, l(3)84Ab, BG:DS00004.13, TAFII-250, Umbilical, TAF250/230, Cell, Cord, dTAF230, TAFII250, Body Fat, placentae (exact, medulla ossium, p230, chemical analysis, whole membrane, TAF[[II]]250/230, TFIID, MscS, connecting stalk, Taf[[II]]250, Yellow Marrow, transmembrane, TAF[[II]]230, medullary bone, medulla of bone, allantoic placenta, TAF[II]250, Membrane, CG17603, TAF[[II]], DmelCG17603, Taf250, fatty depot, adipose, SR3-5, Placentomes, Placentome, assay, Fat, Bone, TAF230, Placentoma, TAF1"],"name_synonyms":["Adipose, d230, determination, placenta (Spanish, dTAFII250, cyclic nucleotide-regulated small mechanosensitive ion channel, yolk stalk, fat, EfW1, Fat Pad, dmTAF[[II]]230, Membrane Tissues, exact), Fatty Tissue, dmTAF1, Taf230, integral component of membrane, Marrow, medulla ossea, Yellow, Umbilical Cords, Fatty, fatty tissue, placenta, fat tissue, TAF250, Taf200, Pads, dTAF[[II]]250, funiculus umbilicalis., TFIID TAF250, cel, cell, Tissues, membrane region, Tissue, Taf1p, Red Marrow, 胎座 (Japanese, dTAF250, portion of placenta tissue (exact), chorda umbilicalis, Normal, birth cord, Red, region of membrane, bodyfat, Pad, TAF, eutherian placenta, Membrane Tissue, membrane, dTAF[[II]]230, TAF[[II]]250, placentas (exact, Fat Pads, plural), Placentas, Cords, TAF200, integral to membrane, l(3)84Ab, BG:DS00004.13, TAFII-250, Umbilical, TAF250/230, Cell, Cord, dTAF230, TAFII250, Body Fat, placentae (exact, medulla ossium, p230, chemical analysis, whole membrane, TAF[[II]]250/230, TFIID, MscS, connecting stalk, Taf[[II]]250, Yellow Marrow, transmembrane, TAF[[II]]230, medullary bone, medulla of bone, allantoic placenta, TAF[II]250, Membrane, CG17603, TAF[[II]], DmelCG17603, Taf250, fatty depot, adipose, SR3-5, Placentomes, Placentome, assay, Fat, Bone, TAF230, Placentoma, TAF1"],"additional_accession":[]},"is_claimable":false,"name":"Single Cell Transcriptomic Analysis of Clinical-used MSCs Derived From Adipose Tissue, Bone Marrow, Placenta Membrane and Umbilical Cord","description":"Single Cell Transcriptomic Analysis of Clinical-used MSCs Derived From Adipose Tissue, Bone Marrow, Placenta Membrane and Umbilical Cord","dates":{"last_updated":"2025-09-24","first_public":"2023-06-22"},"accession":"PRJNA823376","cross_references":{"GEO":["GSE200161"],"taxon":["9606"],"PubMed":["37474525"]}}