ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR188/069/SRR18850369/SRR18850369_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR188/070/SRR18850370/SRR18850370_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR188/071/SRR18850371/SRR18850371_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR188/070/SRR18850370/SRR18850370_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR188/072/SRR18850372/SRR18850372_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR188/069/SRR18850369/SRR18850369_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR188/071/SRR18850371/SRR18850371_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR188/072/SRR18850372/SRR18850372_2.fastq.gzprimaryOK200GenomicsNational Institute of Immunologyhttps://www.ebi.ac.uk/ena/browser/view/PRJNA830358Mus musculusxref:PubMed:39173945Aberrant activation of cell cycle of terminally-differentiated neurons results in their apoptosis and is known to contribute to neuronal loss in various neurodegenerative disorders like Alzheimer's Disease. However, the mechanisms that regulate Cell Cycle Related Neuronal Apoptosis (CRNA) are poorly understood. miRNA being one of the key components in gene regulation, the study was focused to identify the deregulated miRNA in neurodegeneration. Therefore, we utilized small RNA sequencing technology to compare the miRNA profile in cortical neurons from wild type and transgenic mouse model for AD (TgAD). In our quest to understand the regulation of the cell cycle related genes by miRNA, we identified the miRNA that are deregulated in neurons from TgAD mice. miRNA sequencing data revealed several deregulated miRNA that are known or were predicted to target cell cycle related genes. Overall design: Comparison of the miRNA profile in WT and Transgenic mouse model of Alzheimer's disease.ENAHH, Presenile Alzheimer Dementia, ALZHEIMERS DIS, Alzheimers Diseases, Early Onset, Sclerosis, Nerve, bar, IDOL, Early Onset Alzheimer Disease, Focal Onset, Alzheimer's disease, unspecified (disorder), Hh, ALZHEIMER DIS, Primary Senile Degenerative, AD, unspecified, anon-WO0134654.19, DmelCG4637, [X]Dementia in Alzheimer's disease, Cycle, Mir, MIR, Miranda, Cell Division Cycles, Cycles, LATE ONSET ALZHEIMER DIS, Familial Alzheimer Disease (FAD), MONDOA, Alzheimer Diseases, DAT - Dementia Alzheimer's type, Mrt, Cell Division Cycle, cell-division cycle, Cell Division, mir, Focal Onset Alzheimer's Disease, Late Onset Alzheimer Disease, FOCAL ONSET ALZHEIMERS DIS, Presenile Dementia, Myosin regulatory light chain-interacting protein, AD - Alzheimer's disease, bar-3, Alzheimer Disease, Alzheimer Type Dementia, Cell Cycles, Neuron, ALZHEIMER DIS EARLY ONSET, Alzheimer's disease (disorder), bHLHe36, Presenile, Alzheimers Dementia, Nerve Cell, Idol, Neuro-degenerative disease, Alzheimers disease, 9430057C20Rik, Alzheimer Senile Dementia, Senile, l(3)hh, Disease, Alzheimer disease, Myosin regulatory light chain interacting protein, Alzheimer Syndrome, Acute Confusional Senile Dementia, 6.3.2.-, familial, Alzheimer's Dementia, Cell, Division Cycles, CG4637, Primary Senile Degenerative Dementia, CG12249, [X]Dementia in Alzheimer's disease (disorder), Alzheimer Type, AW228700, Alzheimer Dementias, Alzheimer's Diseases, bar3, Progressive neurodegenerative disorder, NOS, DmelCG12249, Dementia, Alzheimers, l(3)neo56, Nerve Cells, l(3)neo57, Division Cycle, Dementia in Alzheimer's disease, Alzheimer, Mira, Alzheimer's Disease Pathway, Dementias, Alzheimer Type Senile Dementia, Inducible degrader of the LDL-receptor, Neurodegenerative disease, Alzheimer-Type (ATD), Nerve., Alzheimer Dementia, Alzheimer Sclerosis, Senile Dementia, Late Onset, anon-WO0182946.19, Familial (FAD), Acute Confusional, Dementia in Alzheimer's disease (disorder), Cells, MIRA, Alzheimer-Type Dementia (ATD), Alzheimer's Disease, Familial Alzheimer Diseases (FAD), hg, Alzheimer Type Dementia (ATD), Dementia of the Alzheimer's typeHH, Presenile Alzheimer Dementia, ALZHEIMERS DIS, Alzheimers Diseases, Early Onset, Sclerosis, Nerve, bar, IDOL, Early Onset Alzheimer Disease, Focal Onset, Alzheimer's disease, unspecified (disorder), Hh, ALZHEIMER DIS, Primary Senile Degenerative, AD, unspecified, anon-WO0134654.19, DmelCG4637, [X]Dementia in Alzheimer's disease, Cycle, Mir, MIR, Miranda, Cell Division Cycles, Cycles, LATE ONSET ALZHEIMER DIS, Familial Alzheimer Disease (FAD), MONDOA, Alzheimer Diseases, DAT - Dementia Alzheimer's type, Mrt, Cell Division Cycle, cell-division cycle, Cell Division, mir, Focal Onset Alzheimer's Disease, Late Onset Alzheimer Disease, FOCAL ONSET ALZHEIMERS DIS, Presenile Dementia, Myosin regulatory light chain-interacting protein, AD - Alzheimer's disease, bar-3, Alzheimer Disease, Alzheimer Type Dementia, Cell Cycles, Neuron, ALZHEIMER DIS EARLY ONSET, Alzheimer's disease (disorder), bHLHe36, Presenile, Alzheimers Dementia, Nerve Cell, Idol, Neuro-degenerative disease, Alzheimers disease, 9430057C20Rik, Alzheimer Senile Dementia, Senile, l(3)hh, Disease, Alzheimer disease, Myosin regulatory light chain interacting protein, Alzheimer Syndrome, Acute Confusional Senile Dementia, 6.3.2.-, familial, Alzheimer's Dementia, Cell, Division Cycles, CG4637, Primary Senile Degenerative Dementia, CG12249, [X]Dementia in Alzheimer's disease (disorder), Alzheimer Type, AW228700, Alzheimer Dementias, Alzheimer's Diseases, bar3, Progressive neurodegenerative disorder, NOS, DmelCG12249, Dementia, Alzheimers, l(3)neo56, Nerve Cells, l(3)neo57, Division Cycle, Dementia in Alzheimer's disease, Alzheimer, Mira, Alzheimer's Disease Pathway, Dementias, Alzheimer Type Senile Dementia, Inducible degrader of the LDL-receptor, Neurodegenerative disease, Alzheimer-Type (ATD), Nerve., Alzheimer Dementia, Alzheimer Sclerosis, Senile Dementia, Late Onset, anon-WO0182946.19, Familial (FAD), Acute Confusional, Dementia in Alzheimer's disease (disorder), Cells, MIRA, Alzheimer-Type Dementia (ATD), Alzheimer's Disease, Familial Alzheimer Diseases (FAD), hg, Alzheimer Type Dementia (ATD), Dementia of the Alzheimer's typefalsemiR-449a may prevent neurodegeneration in Alzheimer's Disease by repressing the cell cycle machinery in neuronsmiR-449a may prevent neurodegeneration in Alzheimer's Disease by repressing the cell cycle machinery in neurons2025-09-242022-04-26PRJNA830358GSE2012091009039173945