{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics","Multiomics"],"center_name":["UCLA"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA85029"],"scientific_name":["Homo sapiens"],"long_description":["Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. Keywords: other"],"tag":["xref:PubMed:12970564"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Homo sapiens","description":"Leprosy lesion gene expression","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA85029","cross_references":{"GEO":["GSE443"],"taxon":["9606"],"PubMed":["12970564"]}}