ENAGenomicsMultiomicsUCLAhttps://www.ebi.ac.uk/ena/browser/view/PRJNA85029Homo sapiensLeprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. Keywords: otherxref:PubMed:12970564ENAfalseHomo sapiensLeprosy lesion gene expression2025-09-242014-02-11PRJNA85029GSE443960612970564