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Jiao Tong Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA859559Coptis sp.xref:EuropePMC:PMC9889990HL is one of the traditional chinese medicine, exhibits multiple activities, such as anti-inflammation, anti-tumor, and anti-diabetes. it is reported that its anti-diabetes activity is highly associated with the alteration of gut microbiota.We used high-fat diet (HFD) with streptozotocin injection to induce T2D in C57BL/6 mice. One group of these mice were administered with HL by oral gavage after 2 weeks of diet intervention and continued for additional 4 weeks (DM-HL group), and the others were given distilled water as disease control (DM group). To determine the overall microbial structure after HL treatment, we sequenced the 16S rRNA gene V3-V4 region of fecal samples collected at the end of trial across all groups (NC group, DM group, DM-HL group), using Illuminar Miseq platform.ENAfalseStudy on the modulation of Rhizoma Coptidis (HL) on gut microbiota and its role in alleviating HFD/STZ-treated mice.Study on the modulation of Rhizoma Coptidis (HL) on gut microbiota and its role in alleviating HFD/STZ-treated mice. Targeted loci2023-05-192023-01-27PRJNA8595592966372