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Although its propensity to form condensates has been studied in the context of neurodegenerative diseases, the physiological role of PrLD remains unclear. Here, we investigated the physiological role of PrLD in NFAR2, generated by a splicing variant of the Ilf3 gene. Removal of the PrLD in mice affected the chronic water immersion and restraint stress (WIRS)-sensitive nuclear localization of NFAR2 in the amygdala, a fear-related brain region. Since NFAR2 regulates transcription and translation in the nucleus and cytoplasm, respectively, we investigated the effects of the PrLD deletion and WIRS on gene expression using RNA-seq and ribosome profiling. Overall design: RNA-seq and ribosome profiling in the amygdala from Ilf3+/+ and Ilf3∆PrLD/∆PrLD mice under WIRS and control conditions"],"tag":["xref:PubMed:36876121"],"repository":["ENA"],"description_synonyms":["protein translation, NF110b, NFAR2, Nucleus Amygdalae, Laboratory, CBTF, Mus domesticus, Amygdaloid Bodies, NF90b, NF90a, House Mouse, amygdaloid nuclear complex, Intercalatas, Intercalata, Corpus Amygdaloideums, Corpus Amygdaloideum, ubp3, ubp4, archistriatum, House, Messenger, Mus musculus domesticus, Complices, NF110, Amygdaloid Nuclear, Encephalopathy Virus, Prion, Mice, Non Polyadenylated, Nucleus, Massa Intercalatas, Swiss, Polyadenylated Messenger, Corpus, Complex, messenger RNA, Nuclear Complex, cbtf122, Swiss Mice, Amygdaloid Nuclear Complex, Mink, Amygdalae, NFAR-1, anxiety., Amygdaloid Body, template RNA, corpus amygdalae, Mink Encephalopathy Virus, DRBF, house mouse, Archistriatums, prp(c), Amygdaloid Nuclei, TCP110, RNA, protein anabolism, protein biosynthetic process, NF-AT-90, Polyadenylated, Intercalated, Nuclei, amygdaloid area, mouse, Messenger RNA, amygdaloid nuclear group, DRBP76, prion, MBII-26, nucleus amygdalae, corpus amygdaloideum, MMP4, Amygdaloid Nuclear Complices, xilf3, Amygdaloid Nucleus, Archistriatum, Massa, Mus, Poly(A)+ mRNA, prp, protein formation, INSDC_feature:mRNA, protein biosynthesis, Amygdaloid, Polyadenylated RNA, amygdaloid nucleus, Nuclear Complices, Polyadenylated Messenger RNA, ilf3, Mus musculus, Intercalated Amygdaloid Nucleus, Poly(A)+ RNA, Non Polyadenylated mRNA, TCP80, protein_coding_transcript, mRNA, Poly(A) Tail, 4F.1, NFAR, mice, Swiss Mouse, Non-Polyadenylated, House Mice, cjd, Non-Polyadenylated mRNA, domesticus, Laboratory Mice, Intercalated Amygdaloid Nuclei, MPP4, amygdaloid body, Amygdaloideums, protein synthesis, ilf3-A, NF90, Massa Intercalata, Amygdaloideum, Mouse, Polyadenylated mRNA, MPHOSPH4, amygdaloid complex, Poly(A) RNA, Laboratory Mouse, Intercalated Amygdaloid"],"name_synonyms":["protein translation, NF110b, NFAR2, Nucleus Amygdalae, Laboratory, CBTF, Mus domesticus, Amygdaloid Bodies, NF90b, NF90a, House Mouse, amygdaloid nuclear complex, Intercalatas, Intercalata, Corpus Amygdaloideums, Corpus Amygdaloideum, ubp3, ubp4, archistriatum, House, Messenger, Mus musculus domesticus, Complices, NF110, Amygdaloid Nuclear, Encephalopathy Virus, Prion, Mice, Non Polyadenylated, Nucleus, Massa Intercalatas, Swiss, Polyadenylated Messenger, Corpus, Complex, messenger RNA, Nuclear Complex, cbtf122, Swiss Mice, Amygdaloid Nuclear Complex, Mink, Amygdalae, NFAR-1, anxiety., Amygdaloid Body, template RNA, corpus amygdalae, Mink Encephalopathy Virus, DRBF, house mouse, Archistriatums, prp(c), Amygdaloid Nuclei, TCP110, RNA, protein anabolism, protein biosynthetic process, NF-AT-90, Polyadenylated, Intercalated, Nuclei, amygdaloid area, mouse, Messenger RNA, amygdaloid nuclear group, DRBP76, prion, MBII-26, nucleus amygdalae, corpus amygdaloideum, MMP4, Amygdaloid Nuclear Complices, xilf3, Amygdaloid Nucleus, Archistriatum, Massa, Mus, Poly(A)+ mRNA, prp, protein formation, INSDC_feature:mRNA, protein biosynthesis, Amygdaloid, Polyadenylated RNA, amygdaloid nucleus, Nuclear Complices, Polyadenylated Messenger RNA, ilf3, Mus musculus, Intercalated Amygdaloid Nucleus, Poly(A)+ RNA, Non Polyadenylated mRNA, TCP80, protein_coding_transcript, mRNA, Poly(A) Tail, 4F.1, NFAR, mice, Swiss Mouse, Non-Polyadenylated, House Mice, cjd, Non-Polyadenylated mRNA, domesticus, Laboratory Mice, Intercalated Amygdaloid Nuclei, MPP4, amygdaloid body, Amygdaloideums, protein synthesis, ilf3-A, NF90, Massa Intercalata, Amygdaloideum, Mouse, Polyadenylated mRNA, MPHOSPH4, amygdaloid complex, Poly(A) RNA, Laboratory Mouse, Intercalated Amygdaloid"],"additional_accession":[]},"is_claimable":false,"name":"mRNA expression and translation regulated by the prion-like domain of Ilf3 in the mouse amygdala under chronic stress","description":"mRNA expression and translation regulated by the prion-like domain of Ilf3 in the mouse amygdala under chronic stress","dates":{"last_updated":"2025-09-24","first_public":"2023-02-15"},"accession":"PRJNA862900","cross_references":{"GEO":["GSE209902"],"taxon":["10090"],"PubMed":["36876121"]}}