{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR209/068/SRR20966568/SRR20966568.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR209/064/SRR20966564/SRR20966564.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR209/070/SRR20966570/SRR20966570.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR209/069/SRR20966569/SRR20966569.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR209/067/SRR20966567/SRR20966567.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR209/072/SRR20966572/SRR20966572.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR209/071/SRR20966571/SRR20966571.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR209/066/SRR20966566/SRR20966566.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR209/065/SRR20966565/SRR20966565.fastq.gz"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Fred Hutchinson Cancer Research Center"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA867402"],"scientific_name":["Sus scrofa"],"tag":["xref:PubMed:36728804"],"long_description":["DUX4 and its mouse ortholog Dux are normally expressed in the early embryo—the 4 cell or 2 cell cleavage stage embryo, respectively—and activate a portion of the first wave of zygotic gene expression. DUX4 is epigenetically suppressed in nearly all somatic tissue, whereas FSHD-causing mutations result in its aberrant expression in skeletal muscle, transcriptional activation of the early embryonic program, and subsequent muscle pathology. Although DUX4 and Dux both activate an early totipotent transcriptional program, divergence of their DNA binding domains limits the use of DUX4 expressed in mice as a pre-clinical model for FSHD. In this study, we identify the porcine DUXC mRNA expressed in early development and show that both pig DUXC and human DUX4 robustly activate a highly similar early embryonic program in pig muscle cells. These results support further investigation of pig preclinical models for FSHD. Overall design: Overexpression of human DUX4, pig DUXC, or GFP control in primary pig myoblasts."],"repository":["ENA"],"description_synonyms":["Facioscapulohumeral myopathy, Landouzy-Dejerine Dystrophies, FSH dystrophy, human being, DUX4, Facioscapulohumeral, Modern, Progressive Muscular Dystrophy, Landouzy Dejerine, muscular dystrophy, Facioscapulohumeral Muscular Dystrophy, Landouzy-Dejerine muscular dystrophy., Human, DUX10, Programs, Facioscapulohumeral muscular dystrophy, Facio-Scapulo-Humeral Dystrophy, FSHD, Homo sapiens, Landouzy Dejerine muscular dystrophy, Dystrophies, Landouzy Dejerine Dystrophy, Muscular Dystrophies, Facioscapulohumeral Type Progressive Muscular Dystrophy, Man, Facioscapulohumeral Type, Atrophies, Facioscapulohumeral Muscular, Embryonic, Landouzy-Dejerine myopathy, facioscapulohumeral myopathy, Man (Taxonomy), FMD - Facioscapulohumeral muscular dystrophy, Facioscapulohumeral Atrophy, Atrophy, facioscapulohumeral muscular dystrophy, DUX4L, Landouzy-Dejerine Dystrophy, Facioscapulohumeral muscular dystrophy (disorder), Muscular Dystrophy, human, FSH - Facioscapulohumeral muscular dystrophy, Landouzy-Dejerine, FSHD - Facioscapulohumeral muscular dystrophy, Facioscapuloperoneal Muscular Dystrophy, Facioscapulohumeral Muscular Dystrophies, facioscapulohumeral dystrophy, Modern Man, species, Fascioscapulohumeral muscular dystrophy, Facioscapulohumeral Atrophies, FSH Muscular Dystrophy, Landouzy-Déjérine muscular dystrophy, Dystrophy"],"name_synonyms":["Facioscapulohumeral myopathy, Landouzy-Dejerine Dystrophies, FSH dystrophy, human being, DUX4, Facioscapulohumeral, Modern, Progressive Muscular Dystrophy, Landouzy Dejerine, muscular dystrophy, Facioscapulohumeral Muscular Dystrophy, Landouzy-Dejerine muscular dystrophy., Human, DUX10, Programs, Facioscapulohumeral muscular dystrophy, Facio-Scapulo-Humeral Dystrophy, FSHD, Homo sapiens, Landouzy Dejerine muscular dystrophy, Dystrophies, Landouzy Dejerine Dystrophy, Muscular Dystrophies, Facioscapulohumeral Type Progressive Muscular Dystrophy, Man, Facioscapulohumeral Type, Atrophies, Facioscapulohumeral Muscular, Embryonic, Landouzy-Dejerine myopathy, facioscapulohumeral myopathy, Man (Taxonomy), FMD - Facioscapulohumeral muscular dystrophy, Facioscapulohumeral Atrophy, Atrophy, facioscapulohumeral muscular dystrophy, DUX4L, Landouzy-Dejerine Dystrophy, Facioscapulohumeral muscular dystrophy (disorder), Muscular Dystrophy, human, FSH - Facioscapulohumeral muscular dystrophy, Landouzy-Dejerine, FSHD - Facioscapulohumeral muscular dystrophy, Facioscapuloperoneal Muscular Dystrophy, Facioscapulohumeral Muscular Dystrophies, facioscapulohumeral dystrophy, Modern Man, species, Fascioscapulohumeral muscular dystrophy, Facioscapulohumeral Atrophies, FSH Muscular Dystrophy, Landouzy-Déjérine muscular dystrophy, Dystrophy"],"additional_accession":[]},"is_claimable":false,"name":"Porcine DUXC and human DUX4 activate similar embryonic programs cross species: implications for preclinical model of FSHD","description":"Porcine DUXC and human DUX4 activate similar embryonic programs cross species: implications for preclinical model of FSHD","dates":{"last_updated":"2025-09-24","first_public":"2023-05-17"},"accession":"PRJNA867402","cross_references":{"GEO":["GSE210772"],"taxon":["9823"],"PubMed":["36728804"]}}