{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR212/094/SRR21201594/SRR21201594_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR212/095/SRR21201595/SRR21201595_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR212/096/SRR21201596/SRR21201596_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR212/093/SRR21201593/SRR21201593_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR212/093/SRR21201593/SRR21201593_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR212/094/SRR21201594/SRR21201594_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR212/095/SRR21201595/SRR21201595_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR212/096/SRR21201596/SRR21201596_1.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["University of Chicago"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA873688"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:37478845"],"long_description":["The FTO gene locus has been linked to cancer and obesity through encoded N6-methyladenosine (m6A) demethylase FTO or inherited genomic variants (e.g. intronic single-nucleotide polymorphisms). Here we demonstrate that FTO-IT1, a long noncoding RNA (lncRNA) transcribed from a FTO gene intron, is upregulated during prostate cancer (PCa) progression and positively correlated with poor survival of patients with tumors only expressing wild-type p53. We show that RBM15, a mRNA/substrate binding subunit of the m6A methyltransferase complex binds and increases mRNA m6A methylation and stability of p53 transcriptional target genes however, FTO-IT1 overexpression abolishes these effects by blocking RBM15 binding of p53 target gene mRNAs. Therapeutic targeting of FTO-IT1 restores mRNA m6A level and p53 signaling and inhibits PCa tumor growth in mice. Our study identifies FTO-IT1 lncRNA as a bono fide inhibitor of m6A methylation and p53 tumor suppression and nominates FTO-IT1 as a potential biomarker and therapeutic target of cancer. Overall design: [Dataset 1] 4 samples. Duplicates for CLIP-Seq samples with an antibody against RBM15 in 22Rv1 (CRL-2505) human prostate carcinoma cell line"],"repository":["ENA"],"description_synonyms":["beta[[3]]-Tub, Non-Translated RNA, DmelCG17117, dp53, p50, LINC RNA, ALKBH9, Neoplasms, p53, Long Non-Translated, Benign Neoplasm, GPM6, Gpm6, Long ncRNAs, 143391_i_at, beta3 TU, Tumor, Long Intergenic Non Protein Coding RNA, LFS1, betaTub3, Malignant, Tp53, l(3)05745, Noncoding RNA, Long Non Translated, DMP53, Messenger, bbl, Long Non-Translated RNA, AA959943, Alleviating interaction, Dmp53, LincRNAs, anon-EST:Liang-2.13, Non Polyadenylated, Long Non-Protein-Coding, Long Non-Coding, lncRNA, 1323/07, clone 2.13, BCC7, Malignancy, Non-Protein-Coding RNA, D.m.BETA-60D, Polyadenylated Messenger, beta-Tub6D, dmp53, inhibiteur, messenger RNA, T, DmP53, 1422/04, INSDC_feature:ncRNA, Acts, Neoplasias, N(6)mAdo, B3t, template RNA, DmelCG3401, Trp53, inhibidor, Long Non-Protein-Coding RNA, N(6)-methyladenosine, Dp53, betaTub60C, beta3-tubulin, Malignancies, beta[[3]]-tubulin, TRP53, CG17117, Long Noncoding RNA, Methylations, Long Untranslated, p50/tubulin, Long Untranslated RNA, Cancer, Tumors, Acta-2, inhibitors, beta-Tub60D, CG10873, RNA, Long Non-Coding RNA, Dmbeta3, Dm-HTH, Malignant Neoplasm, Polyadenylated, ncRNA, ncRNAs, AW743446, BETA 60D, prac, N6-methyladenosine (m6A), IME4, beta3t, beta3-Tub, Actsk-1, Messenger RNA, inhibitor, Long ncRNA, Xp53, m(6)A, 3t, Benign, Non-Coding RNA, Poly(A)+ mRNA, p53/tubulin, MT-A70, Neoplasm, INSDC_feature:mRNA, Long Non Protein Coding RNA, bfy, Polyadenylated RNA, methylation, beta[[3]] tubulin, Long, Untranslated RNA, N6-methyladenosine, RGD1305121, Tub60D, HTH, Hth, suppressive genetic interaction (sensu inequality)., Long Non Coding RNA, antagonists, Polyadenylated Messenger RNA, Spo8, CG33336, beta-tub, Poly(A)+ RNA, Non Polyadenylated mRNA, protein_coding_transcript, mRNA, Poly(A) Tail, DmelCG33336, D-p53, Non-Polyadenylated, beta60C, CG3401, beta3Tub, beta3TUB, Benign Neoplasms, Dm-P53, l(3)86Ca, beta3, Cancers, M6A, Non-Polyadenylated mRNA, dtl, 6-methyladenosine, Malignant Neoplasms, Tub, DTB3, 2310024F18Rik, Meis1, hth1, Long Intergenic Non-Protein Coding RNA, hth2, antagonists and inhibitors, betatub60D, P53, LincRNA, p44, bhy, mKIAA1752, Polyadenylated mRNA, M6a, m6A, other neoplasm, Poly(A) RNA, CG31325, Neoplasia, betaTub"],"name_synonyms":["beta[[3]]-Tub, Non-Translated RNA, DmelCG17117, dp53, p50, LINC RNA, ALKBH9, Neoplasms, p53, Long Non-Translated, Benign Neoplasm, GPM6, Gpm6, Long ncRNAs, 143391_i_at, beta3 TU, Tumor, Long Intergenic Non Protein Coding RNA, LFS1, betaTub3, Malignant, Tp53, l(3)05745, Noncoding RNA, Long Non Translated, DMP53, Messenger, bbl, Long Non-Translated RNA, AA959943, Alleviating interaction, Dmp53, LincRNAs, anon-EST:Liang-2.13, Non Polyadenylated, Long Non-Protein-Coding, Long Non-Coding, lncRNA, 1323/07, clone 2.13, BCC7, Malignancy, Non-Protein-Coding RNA, D.m.BETA-60D, Polyadenylated Messenger, beta-Tub6D, dmp53, inhibiteur, messenger RNA, T, DmP53, 1422/04, INSDC_feature:ncRNA, Acts, Neoplasias, N(6)mAdo, B3t, template RNA, DmelCG3401, Trp53, inhibidor, Long Non-Protein-Coding RNA, N(6)-methyladenosine, Dp53, betaTub60C, beta3-tubulin, Malignancies, beta[[3]]-tubulin, TRP53, CG17117, Long Noncoding RNA, Methylations, Long Untranslated, p50/tubulin, Long Untranslated RNA, Cancer, Tumors, Acta-2, inhibitors, beta-Tub60D, CG10873, RNA, Long Non-Coding RNA, Dmbeta3, Dm-HTH, Malignant Neoplasm, Polyadenylated, ncRNA, ncRNAs, AW743446, BETA 60D, prac, N6-methyladenosine (m6A), IME4, beta3t, beta3-Tub, Actsk-1, Messenger RNA, inhibitor, Long ncRNA, Xp53, m(6)A, 3t, Benign, Non-Coding RNA, Poly(A)+ mRNA, p53/tubulin, MT-A70, Neoplasm, INSDC_feature:mRNA, Long Non Protein Coding RNA, bfy, Polyadenylated RNA, methylation, beta[[3]] tubulin, Long, Untranslated RNA, N6-methyladenosine, RGD1305121, Tub60D, HTH, Hth, suppressive genetic interaction (sensu inequality)., Long Non Coding RNA, antagonists, Polyadenylated Messenger RNA, Spo8, CG33336, beta-tub, Poly(A)+ RNA, Non Polyadenylated mRNA, protein_coding_transcript, mRNA, Poly(A) Tail, DmelCG33336, D-p53, Non-Polyadenylated, beta60C, CG3401, beta3Tub, beta3TUB, Benign Neoplasms, Dm-P53, l(3)86Ca, beta3, Cancers, M6A, Non-Polyadenylated mRNA, dtl, 6-methyladenosine, Malignant Neoplasms, Tub, DTB3, 2310024F18Rik, Meis1, hth1, Long Intergenic Non-Protein Coding RNA, hth2, antagonists and inhibitors, betatub60D, P53, LincRNA, p44, bhy, mKIAA1752, Polyadenylated mRNA, M6a, m6A, other neoplasm, Poly(A) RNA, CG31325, Neoplasia, betaTub"],"additional_accession":[]},"is_claimable":false,"name":"A lncRNA from the FTO locus acts as an inhibitor of mRNA m6A methylation and p53 tumor suppression","description":"A lncRNA from the FTO locus acts as an inhibitor of mRNA m6A methylation and p53 tumor suppression","dates":{"last_updated":"2025-09-24","first_public":"2023-07-10"},"accession":"PRJNA873688","cross_references":{"GEO":["GSE212043"],"taxon":["9606"],"PubMed":["37478845"]}}