ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/078/SRR21484178/SRR21484178_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/082/SRR21484182/SRR21484182_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/072/SRR21484172/SRR21484172_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/070/SRR21484170/SRR21484170_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/080/SRR21484180/SRR21484180_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/076/SRR21484176/SRR21484176_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/077/SRR21484177/SRR21484177_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/074/SRR21484174/SRR21484174_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/073/SRR21484173/SRR21484173_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/083/SRR21484183/SRR21484183_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/071/SRR21484171/SRR21484171_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/075/SRR21484175/SRR21484175_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/081/SRR21484181/SRR21484181_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/083/SRR21484183/SRR21484183_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/077/SRR21484177/SRR21484177_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/076/SRR21484176/SRR21484176_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/072/SRR21484172/SRR21484172_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/074/SRR21484174/SRR21484174_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/079/SRR21484179/SRR21484179_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/082/SRR21484182/SRR21484182_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/080/SRR21484180/SRR21484180_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/070/SRR21484170/SRR21484170_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/071/SRR21484171/SRR21484171_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/079/SRR21484179/SRR21484179_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/073/SRR21484173/SRR21484173_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/078/SRR21484178/SRR21484178_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/075/SRR21484175/SRR21484175_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR214/081/SRR21484181/SRR21484181_1.fastq.gzprimaryOK200GenomicsFourth Military Medical Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA877835Mus musculusxref:PubMed:37712419To test the cell-specific function of GPR30 in learning and memory, we generated global GPR30 knockout (KO) mice (Δ3102), astrocyte-specific GPR30 KO (AG-KO) mice and neuron-specific GPR30 KO (NG-KO) mice. We found that GPR30 in astrocytes but not neurons is required to maintain normal learning and memory. To further elucidate the signaling pathway by which GPR30 plays a role in astrocyte function, high-throughput RNA sequencing of hippocampal tissues from Δ3102, AG-KO, and NG-KO mice was performed. Overall design: Comparative gene expression profiling analysis of RNA-seq data for WT, Δ3102, AG-KO, and NG-KO miceENAfalseEffect of depletion of GPR30 on gene expression in female C57BL/6J miceEffect of depletion of GPR30 on gene expression in female C57BL/6J mice2025-09-242023-08-18PRJNA877835GSE2128931009037712419