{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Medical University of Vienna"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA890024"],"long_description":["Dysbiosis of skin microbiota drives the progression of atopic dermatitis (AD). The contribution of the cutaneous phageome to bacterial community compositions in normal and inflamed skin is unknown. Using shotgun metagenomics from skin swabs of healthy individuals and AD patients, we discovered a total of 13586 potential viral contiguous DNA sequences (contigs) distributed over 182 metagenome samples, which could be combined into 164 putative bacteriophage genomes including integrated prophages (15.2%). While the Shannon diversity index for the viral metagenome-assembled genomes (vMAGs) did not correlate with AD, 28 of them differed significantly between normal and AD skin. qPCR validation of three complete vMAGs revealed a discorrelation between phage and host bacterium abundance. These data suggest that normal and inflamed skin harbor distinct phageomes and that specific bacteriophages may contribute to AD pathogenesis through modulating bacterial fitness."],"repository":["ENA"],"description_synonyms":["dermis plus epidermis plus hypodermis, the integument, region of skin, Viral, human being, Oct-11a, pelt, Virus Microbiomes, Otf-11, Skn-li, Viral Microbiomes, Modern, skin zone, integumental organ, epidermis, Human, skin plus hypodermis, Oct11, skin region, Homo sapiens, BC033609, Virus, Skin-1a, tegument, Skin, Man, integumentum commune, Microbiome, skin benign neoplasm, average, Viral Microbiome, Microbiomes, Phageome, Man (Taxonomy), skin, vertebrate integument, dermoid system, Virus Microbiome, entire skin, Skn-1a., SKIN, human, mKIAA0493, Epoc-1, skin organ, portion of skin, vertebrate epidermis, integument, Phageomes, Modern Man, Fam91a1, Otf11, Viromes, entire integument, AV220772, dermal system, skin and subcutaneous tissue, humans"],"additional_accession":[]},"is_claimable":false,"name":"","description":"The phageome in normal and inflamed human skin","dates":{"last_updated":"2023-06-03","first_public":"2023-06-03"},"accession":"PRJNA890024","cross_references":{}}