{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["NIAMS"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA890374"],"scientific_name":["Homo sapiens"],"long_description":["Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infections in the pediatric population characterized by fever, multi-organ involvement and systemic inflammation. Single-cell RNA sequencing was used to evaluate the transcriptomic signature of CD4+ T cells obtained from the peripheral blood of patients with MIS-C before (n=3) and after (n=5) immunomodulatory treatment, along with pediatric controls (n=4). Compared to controls and treated children with MIS-C, T cells obtained from pre-treatment MIS-C patients upregulated genes associated with activation, such as NF-kB signaling. This single-cell transcriptomic data was used in the context of a larger study entitled, \"Notch1-CD22-Dependent Immune Dysregulation in the SARSCoV2-Associated... (for more see dbGaP study page.)"],"repository":["ENA"],"description_synonyms":["dTAF[[II]]230, TAF[[II]]250, d230, Thymus-Dependent Lymphocytes, T-cell surface antigen T4/Leu-3, UNQ9215/PRO34042, T-cell surface antigen T4|Leu-3, TAF200, l(3)84Ab, dTAFII250, BG:DS00004.13, T-Lymphocyte, TAFII-250, sialic acid-binding Ig-like lectin 5, TAF250/230, Muellerian-inhibiting substance, EfW1, AMH, Cell, dTAF230, SIGLECL1, dmTAF[[II]]230, L3T4, TAFII250, T Lymphocyte, dmTAF1, T-cell differentiation antigen L3T4, T-Cell, Taf230, MIF, p230, Siglec5, Ly-4, TAF[[II]]250/230, Anti-Muellerian hormone, TFIID, MIS, TAF250, Taf[[II]]250, Taf200, SLG., dTAF[[II]]250, TAF[[II]]230, TFIID TAF250, cel, cell, T-Cells, T-cell surface glycoprotein CD4, Thymus-Dependent, T, Taf1p, CD4mut, Lymphocytes, TAF[II]250, CG17603, TAF[[II]], Children, Thymus-Dependent Lymphocyte, dTAF250, T Cells, DmelCG17603, Taf250, SR3-5, Cells, CD4, T Cell, TAF, siglec-5, T Lymphocytes, Thymus Dependent Lymphocytes, Siglece, TAF230, Lymphocyte, TAF1"],"name_synonyms":["dTAF[[II]]230, TAF[[II]]250, d230, Thymus-Dependent Lymphocytes, T-cell surface antigen T4/Leu-3, UNQ9215/PRO34042, T-cell surface antigen T4|Leu-3, TAF200, l(3)84Ab, dTAFII250, BG:DS00004.13, T-Lymphocyte, TAFII-250, sialic acid-binding Ig-like lectin 5, TAF250/230, Muellerian-inhibiting substance, EfW1, AMH, Cell, dTAF230, SIGLECL1, dmTAF[[II]]230, L3T4, TAFII250, T Lymphocyte, dmTAF1, T-cell differentiation antigen L3T4, T-Cell, Taf230, MIF, p230, Siglec5, Ly-4, TAF[[II]]250/230, Anti-Muellerian hormone, TFIID, MIS, TAF250, Taf[[II]]250, Taf200, SLG., dTAF[[II]]250, TAF[[II]]230, TFIID TAF250, cel, cell, T-Cells, T-cell surface glycoprotein CD4, Thymus-Dependent, T, Taf1p, CD4mut, Lymphocytes, TAF[II]250, CG17603, TAF[[II]], Children, Thymus-Dependent Lymphocyte, dTAF250, T Cells, DmelCG17603, Taf250, SR3-5, Cells, CD4, T Cell, TAF, siglec-5, T Lymphocytes, Thymus Dependent Lymphocytes, Siglece, TAF230, Lymphocyte, TAF1"],"additional_accession":[]},"is_claimable":false,"name":"Single cell transcriptomic data from CD4+ T cells from children with MIS-C","description":"Single cell transcriptomic data from CD4+ T cells from children with MIS-C","dates":{"last_updated":"2025-09-24","first_public":"2022-11-18"},"accession":"PRJNA890374","cross_references":{"taxon":["9606"]}}