{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Prinses Máxima Centrum voor kinderoncologie"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA896953"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:36823395"],"long_description":["To investigate the therapeutic potential of targeting RUNX1/ETO with lipid nanoparticles encapsulating chemically modefied siRNA. Gene expression profiling was performing on cells lines after lipid nanoparticles in vitro and on harvested cells from treated mice in vivo. Overall design: Comparative gene expression profiling analysis of RNA-seq data for Kasumi-1 and KSNO-1 cells from in vitro treatment with active siRNA against RUNX1/ETO (LNP/siRE-mod) and control siRNA (LNP/siMM-mod). In vivo treatment of RG mice engrafted with Kasumi-1 cells and treated with active siRNA against RUNX1/ETO (LNP/siRE-mod) and control siRNA (LNP/siMM-mod)"],"repository":["ENA"],"description_synonyms":["Myelogenous Leukemias, Myelocytic, 2-Epoxyaethan, Acute Myeloblastic, acute myeloblastic leukemia, Materials, Nonlymphocytic Leukemia, acute non lymphoblastic leukemia, Myeloid, ZMYND2, acute myeloblastic leukaemia, acute myelogenous leukaemia, Nanocrystalline, CDR, Myelocytic Leukemia, Gene, RNA-seq., Acute Myeloid, Nanocrystal, Acute Myelocytic Leukemias, Cbfa2, acute non lymphoblastic leukaemia, 1, Acute Myelocytic, Acute Nonlymphoblastic, Whole Transcriptome Shotgun Sequencing, acute myeloid, Myeloblastic Leukemia, Runx-1, Pebp2a2, Leukemia, Genetic, AMLCR1, Acute Myelogenous, Acute Myeloblastic Leukemia, epoxyethane, Myelogenous Leukemia, Acute Nonlymphocytic Leukemias, amlcr1, Dimethylene oxide, pebp2ab, aml1, Cbfa2t1h, XAML, Acute Myeloid Leukemia without Maturation, Acute Nonlymphoblastic Leukemia, Acute Nonlymphocytic Leukemia, Pebpa2b, Myeloid Leukemia, Myelocytic Leukemias, Nanocrystals, ANLL, Nonlymphoblastic Leukemias, ethene oxide, Nanocrystalline Material, acute myelogenous, Amprolene, ETO, leukemia, Myelogenous, Anprolene, M1, Nanoparticle, CBF-alpha-2, Oxacyclopropane, M2, Anproline, acute myelogenous leukemia, Nanocrystalline Materials, Aml1, AML1, Cistrons, MTG8, Oxyfume, Leukemias, AML, Acute Myelocytic Leukemia, Nonlymphoblastic Leukemia, Nonlymphocytic Leukemias, Nonlymphoblastic, EVI-1, PEBP2aB, Acute Myeloid Leukemias, Oxidoethane, Myeloid Leukemias, CBFA2T1, Genetic Materials, Dihydrooxirene, AI462102, aml1-evi-1, Acute Nonlymphocytic, cbfa2, evi-1, Genetic Material, Acute Myelogenous Leukemia, Oxane, aml, acute, Acute myelogenous leukemia, AML1-EVI-1, Myeloblastic, Xaml1, 2-epoxyethane, susceptibility to, Myeloblastic Leukemias, Acute Myeloid Leukemia, acute myeloid leukemia, acute myeloid leukaemia, INSDC_feature:gene, CBFA2, Nonlymphocytic, oxyde d'ethylene, Acute Myeloid Leukemia with Maturation, AML1T1, Acute, Material, Acute Nonlymphoblastic Leukemias, Acute Myeloblastic Leukemias, Aethylenoxid, aml-1, Acute Myelogenous Leukemias, Cistron, Ethylene oxide, AML - acute Myeloid Leukemia"],"name_synonyms":["Myelogenous Leukemias, Myelocytic, 2-Epoxyaethan, Acute Myeloblastic, acute myeloblastic leukemia, Materials, Nonlymphocytic Leukemia, acute non lymphoblastic leukemia, Myeloid, ZMYND2, acute myeloblastic leukaemia, acute myelogenous leukaemia, Nanocrystalline, CDR, Myelocytic Leukemia, Gene, RNA-seq., Acute Myeloid, Nanocrystal, Acute Myelocytic Leukemias, Cbfa2, acute non lymphoblastic leukaemia, 1, Acute Myelocytic, Acute Nonlymphoblastic, Whole Transcriptome Shotgun Sequencing, acute myeloid, Myeloblastic Leukemia, Runx-1, Pebp2a2, Leukemia, Genetic, AMLCR1, Acute Myelogenous, Acute Myeloblastic Leukemia, epoxyethane, Myelogenous Leukemia, Acute Nonlymphocytic Leukemias, amlcr1, Dimethylene oxide, pebp2ab, aml1, Cbfa2t1h, XAML, Acute Myeloid Leukemia without Maturation, Acute Nonlymphoblastic Leukemia, Acute Nonlymphocytic Leukemia, Pebpa2b, Myeloid Leukemia, Myelocytic Leukemias, Nanocrystals, ANLL, Nonlymphoblastic Leukemias, ethene oxide, Nanocrystalline Material, acute myelogenous, Amprolene, ETO, leukemia, Myelogenous, Anprolene, M1, Nanoparticle, CBF-alpha-2, Oxacyclopropane, M2, Anproline, acute myelogenous leukemia, Nanocrystalline Materials, Aml1, AML1, Cistrons, MTG8, Oxyfume, Leukemias, AML, Acute Myelocytic Leukemia, Nonlymphoblastic Leukemia, Nonlymphocytic Leukemias, Nonlymphoblastic, EVI-1, PEBP2aB, Acute Myeloid Leukemias, Oxidoethane, Myeloid Leukemias, CBFA2T1, Genetic Materials, Dihydrooxirene, AI462102, aml1-evi-1, Acute Nonlymphocytic, cbfa2, evi-1, Genetic Material, Acute Myelogenous Leukemia, Oxane, aml, acute, Acute myelogenous leukemia, AML1-EVI-1, Myeloblastic, Xaml1, 2-epoxyethane, susceptibility to, Myeloblastic Leukemias, Acute Myeloid Leukemia, acute myeloid leukemia, acute myeloid leukaemia, INSDC_feature:gene, CBFA2, Nonlymphocytic, oxyde d'ethylene, Acute Myeloid Leukemia with Maturation, AML1T1, Acute, Material, Acute Nonlymphoblastic Leukemias, Acute Myeloblastic Leukemias, Aethylenoxid, aml-1, Acute Myelogenous Leukemias, Cistron, Ethylene oxide, AML - acute Myeloid Leukemia"],"additional_accession":[]},"is_claimable":false,"name":"Nanoparticle-mediated Targeting of the Fusion Gene RUNX1/ETO in t(8 21)-positive Acute Myeloid Leukemia [RNA-seq]","description":"Nanoparticle-mediated Targeting of the Fusion Gene RUNX1/ETO in t(8 21)-positive Acute Myeloid Leukemia [RNA-seq]","dates":{"last_updated":"2025-09-24","first_public":"2022-11-17"},"accession":"PRJNA896953","cross_references":{"GEO":["GSE217109"],"taxon":["9606"],"PubMed":["36823395"]}}