{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Prinses Máxima Centrum voor kinderoncologie"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA896960"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:36823395"],"long_description":["To investigate the therapeutic potential of targeting RUNX1/ETO with lipid nanoparticles encapsulating chemically modefied siRNA. Epegnomic profiling was performing on cells lines after lipid nanoparticles in vitro. Overall design: Comparative epegnomic profiling of RUNX1/ETO, RUNX1 and CEBFB for Kasumi-1 and KSNO-1 cells from in vitro treatment with active siRNA against RUNX1/ETO (LNP/siRE-mod, KD) and control siRNA (LNP/siMM-mod, Ctrl)."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Nanoparticle-mediated Targeting of the Fusion Gene RUNX1/ETO in t(8 21)-positive Acute Myeloid Leukemia [CUT&RUN]","description":"Nanoparticle-mediated Targeting of the Fusion Gene RUNX1/ETO in t(8 21)-positive Acute Myeloid Leukemia [CUT&RUN]","dates":{"last_updated":"2025-09-24","first_public":"2022-11-17"},"accession":"PRJNA896960","cross_references":{"GEO":["GSE217110"],"taxon":["9606"],"PubMed":["36823395"]}}