ENAGenomicsPrinses Máxima Centrum voor kinderoncologiehttps://www.ebi.ac.uk/ena/browser/view/PRJNA896960Homo sapiensxref:PubMed:36823395To investigate the therapeutic potential of targeting RUNX1/ETO with lipid nanoparticles encapsulating chemically modefied siRNA. Epegnomic profiling was performing on cells lines after lipid nanoparticles in vitro. Overall design: Comparative epegnomic profiling of RUNX1/ETO, RUNX1 and CEBFB for Kasumi-1 and KSNO-1 cells from in vitro treatment with active siRNA against RUNX1/ETO (LNP/siRE-mod, KD) and control siRNA (LNP/siMM-mod, Ctrl).ENAfalseNanoparticle-mediated Targeting of the Fusion Gene RUNX1/ETO in t(8 21)-positive Acute Myeloid Leukemia [CUT&RUN]Nanoparticle-mediated Targeting of the Fusion Gene RUNX1/ETO in t(8 21)-positive Acute Myeloid Leukemia [CUT&RUN]2025-09-242022-11-17PRJNA896960GSE217110960636823395