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University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA900189"],"long_description":["The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis (RA) remain poorly defined. Although increased levels of CD8+ T cells have been described in RA, their role in pathogenesis remains unclear. Here we perform single cell transcriptome and T cell receptor (TCR) sequencing of CD8+ T cells derived from RA blood. We identify GZMB+CD8+ subpopulations containing large clonal lineage expansions that express cytotoxic and tissue homing transcriptional programs, while a GZMK+CD8+ memory subpopulation comprises of smaller clonal expansions that express effector T cell transcriptional programs. We demonstrate RA citrullinated autoantigens presented by MHC class I activate RA blood-derived GZMB+CD8+ T cells to expand, express cytotoxic mediators, and mediate killing of target cells. We also demonstrate that these clonally expanded GZMB+CD8+ cells are present in RA synovium"],"repository":["ENA"],"description_synonyms":["Thymus-Dependent Lymphocytes, T-Cells, p32, susceptibility to, Thymus-Dependent, Leu2, T, Lymphocytes, T-Lymphocyte, Cell, Thymus-Dependent Lymphocyte, RA., T Cells, Rheumatoid Arthritis, T Lymphocyte, T-Cell, rheumatoid arthritis, Cells, Antigen, T Cell, CD8, Rheumatoid arthritis, MAL, T Lymphocytes, Thymus Dependent Lymphocytes, Lymphocyte"],"additional_accession":[]},"is_claimable":false,"name":"","description":"Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis","dates":{"last_updated":"2023-05-19","first_public":"2022-12-02"},"accession":"PRJNA900189","cross_references":{}}