ENAGenomicsUniversity of Paduahttps://www.ebi.ac.uk/ena/browser/view/PRJNA902542Kv1.3 is a voltage-gated potassium channel with multiple functions within excitable and nonexcitable cells. Altered expression and/or function of Kv1.3 is linked to a plethora of diseases, including cancer. Kv1.3 represents a promising oncological target however, how Kv1.3 is involved in cancer progression is not yet fully clear. We hypothesize that, in addition to modulating cell physiology by allowing potassium flux through the plasma membrane and intracellular membranes, Kv1.3 could function during tumorigenesis by participating in signaling complexes.We explored the intact cell interactome of Kv1.3, identifying cancer-related pathways regulated by the expression of the channel. These results lay the basis for understanding how ion channels may participate in tumor progression and expand the palette of useful tools to determine the ion channel integrative network. Collectively, our studies provide a valuable resource to uncover novel Kv1.3 biology and inform the development of potential therapeutics.xref:EuropePMC:PMC11373599ENAfalseKV1.3 INTACT CELL INTERACTOME2024-05-112024-05-11PRJNA902542