{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Cancer Biomarkers, Institute for Stem-cell Biology, Regenerative Medicine and Innovative Therapies (ISBReMIT), Fondazione IRCCS Casa Sollievo della Sofferenza"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA925828"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:37406967"],"long_description":["Acute promyelocytic leukemia (APL) is a hematological disease characterized by a balanced reciprocal translocation that leads to the synthesis of the oncogenic fusion protein PML-RARα. APL is mainly managed by a differentiation therapy based on the administration of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, therapy resistance, differentiation syndrome, and relapses require the development of new low-toxicity therapies based on the induction of blasts differentiation. Here, we performed a high-throughput gene expression profile of the ATRA-resistant acute promyelocytic leukemia (APL) cellline (aka R4) treated with a CHK1 inhibitor or DMSO as control. Overall design: We performed a whole mRNA transcriptome analysis by Affymetrix microarray of R4 cells treated with MK-8776 (4 μM) for 96 h or DMSO as control. Two biological replicates were performed for each condition."],"repository":["ENA"],"description_synonyms":["NB4, inhibitors, Profiling, grp(chk), Transcriptome, Pk?1, Sch-900776, Monitorings, Cell Lines, Gene, inhibitor, MK8776, Cell, l(2)k15102, grps, Gene Expression Profilings, Gene Expression, Differential Display, Transcript Expression Analysis, transcription profiling, mRNA Differential Displays, Transcript Expression Analyses, Gene Expression Pattern Analysis, Gene Expression Monitorings, Line, 1C, Sch900776., Analysis, Profilings, mRNA Differential Display, gene expression profiling, DmChk1, Lines, Gene Expression Monitoring, Grp, CHK1/Grapes, Transcriptome Profiling, Analyses, mRNA, Chk1, Transcriptome Profilings, mR4, Rnase2, inhibiteur, Transcriptomics, Differential Displays, CG17161, Transcript Expression, Transcriptome Analysis, Pk36A, Transcriptome Analyses, RNS2, Monitoring, NB.4, Sch 900776, Gene Expression Analysis, Dchk1, chk1, Gene Expression Analyses, inhibidor, Grp/DChk1, DmelCG17161, rad27, lemp, dChk1, C85740, Expression Analysis, CHK1, Expression Analyses, NB-4"],"name_synonyms":["NB4, inhibitors, Profiling, grp(chk), Transcriptome, Pk?1, Sch-900776, Monitorings, Cell Lines, Gene, inhibitor, MK8776, Cell, l(2)k15102, grps, Gene Expression Profilings, Gene Expression, Differential Display, Transcript Expression Analysis, transcription profiling, mRNA Differential Displays, Transcript Expression Analyses, Gene Expression Pattern Analysis, Gene Expression Monitorings, Line, 1C, Sch900776., Analysis, Profilings, mRNA Differential Display, gene expression profiling, DmChk1, Lines, Gene Expression Monitoring, Grp, CHK1/Grapes, Transcriptome Profiling, Analyses, mRNA, Chk1, Transcriptome Profilings, mR4, Rnase2, inhibiteur, Transcriptomics, Differential Displays, CG17161, Transcript Expression, Transcriptome Analysis, Pk36A, Transcriptome Analyses, RNS2, Monitoring, NB.4, Sch 900776, Gene Expression Analysis, Dchk1, chk1, Gene Expression Analyses, inhibidor, Grp/DChk1, DmelCG17161, rad27, lemp, dChk1, C85740, Expression Analysis, CHK1, Expression Analyses, NB-4"],"additional_accession":[]},"is_claimable":false,"name":"Gene expression profiling of ATRA-resistant NB4-MR4 subclone (R4 cell line) treated with a CHK1 inhibitor i(MK-8776).","description":"Gene expression profiling of ATRA-resistant NB4-MR4 subclone (R4 cell line) treated with a CHK1 inhibitor i(MK-8776).","dates":{"last_updated":"2025-09-24","first_public":"2024-01-02"},"accession":"PRJNA925828","cross_references":{"GEO":["GSE223329"],"taxon":["9606"],"PubMed":["37406967"]}}