{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR233/054/SRR23301954/SRR23301954.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["The Univ of Tokyo"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA930352"],"scientific_name":["Mus musculus"],"tag":["xref:PubMed:39080781"],"long_description":["In rheumatoid arthritis (RA), inflammation and joint destruction are exacerbated by a complicated interaction among immune cells, synovial fibroblasts and bone cells. It remains to be elucidated which cell-cell interaction critically drives the pathogenesis of RA and serves as a therapeutic target for synthetic disease modifying antirheumatic drugs (DMARDs) such as janus kinase (JAK) inhibitors. we performed a scRNA-seq analysis of the synovium of collagen-induced arthritis (CIA) mice treated with JAK inhibitor, followed by a computational analysis to identify the drug target cells and signaling pathways in vivo Overall design: scRNA-seq analysis was performed on synovial cells which were isolated from the knee joints of CIA mice treated with a JAK inhibitor, upadacitinib (n=6). Alignment, quantitation and aggregation of the sample count matrices were performed using the 10x Genomics Cell Ranger pipeline (v.3.0) according to the manufacturer’s protocol (GENEWIZ)."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic analysis of synovial cells derived from collagen-induced arthritis mice treated with a JAK inhibitor, upadacitinib","description":"Transcriptomic analysis of synovial cells derived from collagen-induced arthritis mice treated with a JAK inhibitor, upadacitinib","dates":{"last_updated":"2025-09-24","first_public":"2024-08-26"},"accession":"PRJNA930352","cross_references":{"GEO":["GSE224221"],"taxon":["10090"],"PubMed":["39080781"]}}