ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/048/SRR23595748/SRR23595748_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/054/SRR23595754/SRR23595754_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/056/SRR23595756/SRR23595756_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/050/SRR23595750/SRR23595750_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/046/SRR23595746/SRR23595746_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/045/SRR23595745/SRR23595745_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/052/SRR23595752/SRR23595752_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/053/SRR23595753/SRR23595753_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/049/SRR23595749/SRR23595749_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/055/SRR23595755/SRR23595755_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/051/SRR23595751/SRR23595751_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/045/SRR23595745/SRR23595745_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/052/SRR23595752/SRR23595752_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/046/SRR23595746/SRR23595746_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/055/SRR23595755/SRR23595755_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/049/SRR23595749/SRR23595749_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/047/SRR23595747/SRR23595747_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/053/SRR23595753/SRR23595753_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/050/SRR23595750/SRR23595750_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/056/SRR23595756/SRR23595756_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/048/SRR23595748/SRR23595748_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/051/SRR23595751/SRR23595751_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/054/SRR23595754/SRR23595754_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR235/047/SRR23595747/SRR23595747_2.fastq.gzprimaryOK200GenomicsLiaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Department of Hematology, the Second Hospital of Dalian Medical Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA937919Mus musculusAutologous peripheral hematopoietic stem cell transplantation (autoHSCT) is one front-line therapy with high-dose melphalan for multiple myeloma (MM). Patients with MM who receive conditioning regimen with melphalan usually suffer from severe gastrointestinal symptoms, as one of nonhematological toxicities. Aim: It is an urgent demand to develop an effective methods to repair the intestinal injuries in patients with MM receiving conditioning regimen with high-dose melphalan for autoHSCT. Therefore, the protective effects of Human umbilical cord derived-mesenchymal stem cells (hucMSCs) is investigated after infusion into mouse model with melphalan-induce gastrointestinal injuries. Overall design: Comparative gene expression profiling analysis of RNA-seq data for Control small intestine cells and its treatments (melphalan, melphalan+MSC, and MSC+melphalan).ENAResearch Related Injuries, L-Phenylalanine, Multipotent Bone Marrow Stromal Cells, Mesenchymal Stem Cell, human being, Laboratory, Wound, Phenylalanine mustard, Mesenchymal Stem Cells, Mus domesticus, Stem Cells, Physical, Progenitor Cell, Stromal Cells, 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine, Mesenchymal Stromal Cells, Adipose Tissue Derived Mesenchymal Stromal Cell, Wharton's Jelly Cells, melphalanum, L-Phenylalanine mustard, yolk stalk, Multipotent Mesenchymal Stromal Cell, Phenylalanine nitrogen mustard, injury, House Mouse, Injuries and Wounds, Multipotent Mesenchymal Stromal Cells., trauma, Human, Wounds, Homo sapiens, House, 4-(bis(2-chloroethyl)amino)-, Stromal Cell, p-N, Mus musculus domesticus, Merphalan, Wharton Jelly Cells, Umbilical Cords, protective, Mice, Man, Wharton's Jelly Cell, Research-Related, L-PAM, Adipose Tissue-Derived Mesenchymal Stromal Cells, Adipose Derived Mesenchymal Stem Cells, melphalan, Injury, Man (Taxonomy), Swiss, Sarcolysine, Swiss Mice, Bone Marrow Stromal Stem Cells, Medphalan, p-Di-(2-chloroethyl)amino-L-phenylalanine, Bone Marrow Mesenchymal Stem Cells, Phenylalanine, chorda umbilicalis, Whartons Jelly Cells, L-Sarcolysine, Traumas, birth cord, Phenylalanine Mustard, house mouse, Bone Marrow Mesenchymal Stem Cell, Adipose Derived Mesenchymal Stem Cell, 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine, Adipose-Derived Mesenchymal Stem Cell, Injury and Wounds, Modern, Progenitor Cells, mouse, Cords, Physical Traumas, Mesenchymal Progenitor Cells, Umbilical, Adipose Tissue-Derived Mesenchymal Stem Cell, Cord, funiculus umbilicalis, 4-(Bis(2-chloroethyl)amino)-L-phenylalanine, Mesenchymal Stromal Cell, Stem Cell, Mus, traumatic injury, Wounds and Injury, Trauma, L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine, 4-(Bis(2-chloroethyl)amino)phenylalanine, Physical Trauma, melfalano, connecting stalk, Mus musculus, Bone Marrow Stromal Cell, Adipose-Derived, Adipose-Derived Mesenchymal Stem Cells, p-Bis(beta-chloroethyl)aminophenylalanine, Alkeran, Adipose Tissue Derived Mesenchymal Stromal Cells, mice, decrease in risk, Sarkolysin, Swiss Mouse, wound, Multipotent Bone Marrow Stromal Cell, Adipose Tissue-Derived Mesenchymal Stromal Cell, House Mice, Adipose Tissue Derived Mesenchymal Stem Cells, human, Injuries, domesticus, Laboratory Mice, Adipose-Derived Mesenchymal Stromal Cells, Adipose Derived, Adipose Tissue-Derived Mesenchymal Stem Cells, N-bis(2-chloroethyl)amino-L-phenylalanine, Mesenchymal Progenitor Cell, Modern Man, Multipotent, Mesenchymal, Adipose Derived Mesenchymal Stromal Cells, Research-Related Injuries, Adipose Tissue Derived Mesenchymal Stem Cell, Mouse, Research-Related Injury, Bone Marrow Stromal Cells, Mustard, p-L-Sarcolysin, Laboratory Mouse, p-N-Bis(2-chloroethyl)amino-L-phenylalanineResearch Related Injuries, L-Phenylalanine, Multipotent Bone Marrow Stromal Cells, Mesenchymal Stem Cell, human being, Laboratory, Wound, Phenylalanine mustard, Mesenchymal Stem Cells, Mus domesticus, Stem Cells, Physical, Progenitor Cell, Stromal Cells, 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine, Mesenchymal Stromal Cells, Adipose Tissue Derived Mesenchymal Stromal Cell, Wharton's Jelly Cells, melphalanum, L-Phenylalanine mustard, yolk stalk, Multipotent Mesenchymal Stromal Cell, Phenylalanine nitrogen mustard, injury, House Mouse, Injuries and Wounds, Multipotent Mesenchymal Stromal Cells., trauma, Human, Wounds, Homo sapiens, House, 4-(bis(2-chloroethyl)amino)-, Stromal Cell, p-N, Mus musculus domesticus, Merphalan, Wharton Jelly Cells, Umbilical Cords, protective, Mice, Man, Wharton's Jelly Cell, Research-Related, L-PAM, Adipose Tissue-Derived Mesenchymal Stromal Cells, Adipose Derived Mesenchymal Stem Cells, melphalan, Injury, Man (Taxonomy), Swiss, Sarcolysine, Swiss Mice, Bone Marrow Stromal Stem Cells, Medphalan, p-Di-(2-chloroethyl)amino-L-phenylalanine, Bone Marrow Mesenchymal Stem Cells, Phenylalanine, chorda umbilicalis, Whartons Jelly Cells, L-Sarcolysine, Traumas, birth cord, Phenylalanine Mustard, house mouse, Bone Marrow Mesenchymal Stem Cell, Adipose Derived Mesenchymal Stem Cell, 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine, Adipose-Derived Mesenchymal Stem Cell, Injury and Wounds, Modern, Progenitor Cells, mouse, Cords, Physical Traumas, Mesenchymal Progenitor Cells, Umbilical, Adipose Tissue-Derived Mesenchymal Stem Cell, Cord, funiculus umbilicalis, 4-(Bis(2-chloroethyl)amino)-L-phenylalanine, Mesenchymal Stromal Cell, Stem Cell, Mus, traumatic injury, Wounds and Injury, Trauma, L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine, 4-(Bis(2-chloroethyl)amino)phenylalanine, Physical Trauma, melfalano, connecting stalk, Mus musculus, Bone Marrow Stromal Cell, Adipose-Derived, Adipose-Derived Mesenchymal Stem Cells, p-Bis(beta-chloroethyl)aminophenylalanine, Alkeran, Adipose Tissue Derived Mesenchymal Stromal Cells, mice, decrease in risk, Sarkolysin, Swiss Mouse, wound, Multipotent Bone Marrow Stromal Cell, Adipose Tissue-Derived Mesenchymal Stromal Cell, House Mice, Adipose Tissue Derived Mesenchymal Stem Cells, human, Injuries, domesticus, Laboratory Mice, Adipose-Derived Mesenchymal Stromal Cells, Adipose Derived, Adipose Tissue-Derived Mesenchymal Stem Cells, N-bis(2-chloroethyl)amino-L-phenylalanine, Mesenchymal Progenitor Cell, Modern Man, Multipotent, Mesenchymal, Adipose Derived Mesenchymal Stromal Cells, Research-Related Injuries, Adipose Tissue Derived Mesenchymal Stem Cell, Mouse, Research-Related Injury, Bone Marrow Stromal Cells, Mustard, p-L-Sarcolysin, Laboratory Mouse, p-N-Bis(2-chloroethyl)amino-L-phenylalaninefalseProtective effects on melphalan-induced mouse intestinal injury treated by Human Umbilical Cord-derived Mesenchymal Stem CellsProtective effects on melphalan-induced mouse intestinal injury treated by Human Umbilical Cord-derived Mesenchymal Stem Cells2025-09-242024-04-04PRJNA937919GSE22589910090