ENAapplication/xmlftp://primaryOK200GenomicsCOLUMBIA UNIVERSITY HEALTH SCIENCEShttps://www.ebi.ac.uk/ena/browser/view/PRJNA950542Homo sapiensWe conducted a prospective cohort study of adults (RESERVE-U-C19) admitted to Entebbe Regional Referral Hospital (ERRH), a national COVID-19 referral center, across three viral variant-driven phases of the pandemic in Uganda. In this cohort, which reflects the entire spectrum of SARS-CoV-2 infection, we integrated clinical data with serum proteomics (N=306) and whole-blood transcriptomics (N=100) to determine a range of host responses associated with COVID-19 severity, SARS-CoV-2/HIV co-infection, and circulating viral variants. Beyond the prognostic importance of myeloid cell-driven immune activation and lymphopenia, we show that multifaceted impairment of host protein synthesis and extensive redox imbalance define core metabolic signatures of severe COVID-19, with central roles for IL... (for more see dbGaP study page.)ENAfalseMultimodal immune profiling to determine mechanisms of COVID-19 clinical trajectory in UgandaMultimodal immune profiling to determine mechanisms of COVID-19 clinical trajectory in Uganda2025-09-242023-04-13PRJNA9505429606