{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics","Multiomics"],"center_name":["Stanford University, School of Medicine, Stanford Microarray Database (SMD)"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA95117"],"scientific_name":["Synechocystis sp. PCC 6803"],"long_description":["Abstract: A sensor histidine kinase of Synechococcus sp. strain PCC7942, designated nblS, was previously identified and shown to be critical for the acclimation of cells to high-light and nutrient limitation conditions and to influence the expression of a number of light-responsive genes. The nblS orthologue in Synechocystis sp. strain PCC6803 is designated dspA (also called hik33). We have generated a dspA null mutant and analyzed global gene expression in both the mutant and wild-type strains under high- and low-light conditions. The mutant is aberrant for the expression of many genes encoding proteins critical for photosynthesis, phosphate and carbon acquisition, and the amelioration of stress conditions. Furthermore, transcripts from a number of genes normally detected only during exposure of wild-type cells to high-light conditions become partially constitutive in the low-light-grown dspA mutant. Other genes for which transcripts decline upon exposure of wild-type cells to high light are already lower in the mutant during growth in low light. These results suggest that DspA may influence gene expression in both a positive and a negative manner and that the dspA mutant behaves as if it were experiencing stress conditions (e.g., high-light exposure) even when maintained at near-optimal growth conditions for wild-type cells. This is discussed with respect to the importance of DspA for regulating the responses of the cell to environmental cues. A strain or line experiment design type assays differences between multiple strains, cultivars, serovars, isolates, lines from organisms of a single species. Keywords: strain_or_line_design Overall design: User Defined"],"tag":["xref:PubMed:15175303"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Synechocystis sp. PCC 6803","description":"Consequences of a deletion in dspA on transcript accumulation in Synechocystis sp. strain PCC6803.","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA95117","cross_references":{"GEO":["GSE4019"],"taxon":["1148"],"PubMed":["15175303"]}}