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& Systems Biology, CHDIhttps://www.ebi.ac.uk/ena/browser/view/PRJNA956252Mus musculusxref:PubMed:39938516As part of collaboration between UCLA and CHDI, UCLA is creating knockouts (KOs) of 123 genes, implicated in Huntington’s disease (HD) through various computational modeling efforts. Striatum and cortex were isolated from 6-month-old Mlh1+/- mice crossed with the Q140 knock-in (KI) HD mice and their respective controls. Transcriptomic analysis (RNASeq) was performed on 4 genotypes: WT, Mlh1+/-, Q140, and Q140 X Mlh1+/-, 8 replicates per genotype. Overall design: RNASeq analysis was performed on samples from the striatum and cortex tissues of 6-month-old Mlh1+/-, Q140 KI, Q140 X Mlh1+/-, and wild-type mice. N = 8 per group (3-4F/4-5M).ENAfalseTranscriptional profiling of striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Mlh1 heterozygous mice [Mlh1]Transcriptional profiling of striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Mlh1 heterozygous mice [Mlh1]2025-09-242025-02-12PRJNA956252GSE2298111009039938516