{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR244/000/SRR24413100/SRR24413100.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR244/098/SRR24413098/SRR24413098.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR244/001/SRR24413101/SRR24413101.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR244/096/SRR24413096/SRR24413096.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR244/097/SRR24413097/SRR24413097.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR244/099/SRR24413099/SRR24413099.fastq.gz"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["University of California"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA966397"],"scientific_name":["Mus musculus"],"long_description":["Hepatocyte Nuclear Factor 4α (HNF4α), master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2). P1-HNF4α but not P2-HNF4α is expressed in normal adult liver in fed conditions. Both P1- and P2-HNF4α are expressed in fetal liver. P2-HNF4α expression is increased in fasted conditions, high fat diet, alcoholic liver and liver cancer. To determine the target genes of the P1- and P2-HNF4α isoforms, we compared P2-HNF4α-expressing exon swap mice (a7HMZ) to wildtype (WT) male mice. Liver ChIP-seq samples were taken at 10:30 AM (ZT 3.5) Overall design: Liver ChIP-seq samples from adult WT (P1-HNF4a1) and a7HMZ (P2-HNF4a7) male mice were analyzed in triplicate at 10:30 AM (ZT 3.5)."],"repository":["ENA"],"description_synonyms":["jecur, iecur., Livers, Protein Splice Variant, Protein, adult stage, Variant, Variants, Splice Variants, Protein Splice Variants, Isoforms, Protein Isoform, Isoform, Adults, Protein Splice, adult, Splice Variant"],"name_synonyms":["jecur, iecur., Livers, Protein Splice Variant, Protein, adult stage, Variant, Variants, Splice Variants, Protein Splice Variants, Isoforms, Protein Isoform, Isoform, Adults, Protein Splice, adult, Splice Variant"],"additional_accession":[]},"is_claimable":false,"name":"Developmentally regulated isoform of HNF4α reprograms the adult liver","description":"Developmentally regulated isoform of HNF4α reprograms the adult liver","dates":{"last_updated":"2025-09-24","first_public":"2023-05-17"},"accession":"PRJNA966397","cross_references":{"GEO":["GSE231538"],"taxon":["10090"]}}