ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR244/000/SRR24413100/SRR24413100.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR244/098/SRR24413098/SRR24413098.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR244/001/SRR24413101/SRR24413101.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR244/096/SRR24413096/SRR24413096.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR244/097/SRR24413097/SRR24413097.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR244/099/SRR24413099/SRR24413099.fastq.gzprimary200OKGenomicsUniversity of Californiahttps://www.ebi.ac.uk/ena/browser/view/PRJNA966397Mus musculusHepatocyte Nuclear Factor 4α (HNF4α), master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2). P1-HNF4α but not P2-HNF4α is expressed in normal adult liver in fed conditions. Both P1- and P2-HNF4α are expressed in fetal liver. P2-HNF4α expression is increased in fasted conditions, high fat diet, alcoholic liver and liver cancer. To determine the target genes of the P1- and P2-HNF4α isoforms, we compared P2-HNF4α-expressing exon swap mice (a7HMZ) to wildtype (WT) male mice. Liver ChIP-seq samples were taken at 10:30 AM (ZT 3.5) Overall design: Liver ChIP-seq samples from adult WT (P1-HNF4a1) and a7HMZ (P2-HNF4a7) male mice were analyzed in triplicate at 10:30 AM (ZT 3.5).ENAjecur, iecur., Livers, Protein Splice Variant, Protein, adult stage, Variant, Variants, Splice Variants, Protein Splice Variants, Isoforms, Protein Isoform, Isoform, Adults, Protein Splice, adult, Splice Variantjecur, iecur., Livers, Protein Splice Variant, Protein, adult stage, Variant, Variants, Splice Variants, Protein Splice Variants, Isoforms, Protein Isoform, Isoform, Adults, Protein Splice, adult, Splice VariantfalseDevelopmentally regulated isoform of HNF4α reprograms the adult liverDevelopmentally regulated isoform of HNF4α reprograms the adult liver2025-09-242023-05-17PRJNA966397GSE23153810090