{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Microbial Genetics Division, National Institute of Agricultural Biotechnology"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA97455"],"scientific_name":["Mycobacterium tuberculosis"],"long_description":["The Mycobacterium tuberculosis acyl-CoA carboxylases provide the building blocks for de novo fatty acid biosynthesis by fatty acid synthase (FAS) I and for the elongation of FAS I end-products by the FAS II complex to produce meromycolic acids. M. tuberculosis genome contains three biotin carboxylase subunits (AccA1-3) and 6 carboxyltransferase subunits (AccD1-6) of which AccD6 is located in a genetic locus that contains members of the FAS II complex. We found by microarray and quantitative real-time RT-PCR analysis that the transcripts of AccA3, AccD4, AccD5 and AccD6 are expressed at high levels during exponential growth phases of M. tuberculosis in vitro. Keywords: Time course, developmental stages Overall design: The microarray hybridization was performed to compare general gene expression changes along with Acyl-CoA carboxylase subunits between an exponential growth phase and late-log phase. Wild-type Mtb cells were inoculated in the complete liquid medium, and grown until OD~0.5, which is chosen as a reference exponential growth stage. Samples were prepared after further growth until the OD values doubles in the same medium as was in the reference culture."],"tag":["pathogen:priority","pathogen:bacterium","pathogen","xref:PubMed:17114269"],"classification":["bacteria"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Mycobacterium tuberculosis","description":"Carboxyltransferase Subunit of the Acyl-CoA Carboxylase in Mycobacterium tuberculosis.","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA97455","cross_references":{"GEO":["GSE5977"],"taxon":["1773"],"PubMed":["17114269"]}}