{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR247/029/SRR24710529/SRR24710529_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR247/027/SRR24710527/SRR24710527_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR247/030/SRR24710530/SRR24710530_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR247/030/SRR24710530/SRR24710530_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR247/028/SRR24710528/SRR24710528_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR247/027/SRR24710527/SRR24710527_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR247/025/SRR24710525/SRR24710525_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR247/028/SRR24710528/SRR24710528_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR247/026/SRR24710526/SRR24710526_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR247/029/SRR24710529/SRR24710529_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR247/026/SRR24710526/SRR24710526_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR247/025/SRR24710525/SRR24710525_1.fastq.gz"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Tongji Hospital Affiliated to Tongji University School of Medicine"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA975490"],"scientific_name":["Mus musculus"],"long_description":["Autism spectrum disorder (ASD) is a heterogeneous group of disorders with shared diagnostic phenotypes, such as reduced interest in social interaction and communication, and increased stereotyped or restricted interests and behaviors. Little is known about the involvement of alterations of glutaminase 1 (Gls1, an enzyme that catalyzes the hydrolysis of glutamine into glutamate) in the pathogenesis of ASD. To investigate the role of Gls1 in forebrain neurons , we generated conditional mouse mutants with loss of Gls1 in forebrain CamKIIα-Cre positive neurons by crossing Gls1flox/flox mice with CamKIIαcre mice. Overall design: Conditional mouse mutants with loss of Gls1 in forebrain CamKIIα-Cre positive neurons were generated by crossing Gls1flox/flox mice with CamKIIαcre mice. Mosaic homozygous Gls1 mutant (CamKIIαCre Gls1flox/flox) mice were not viable. Only mosaic heterozygous Gls1 mice (CamKIIαCre Gls1+/flox mice, referred to as Gls1_CamKIIαCre mice) and their littermate CamKIIαCre Gls1+/+ mice (referred to as control mice) were used in this study. The prefrontal cortex from 3 Gls1_CamkIIaCre mice and 3 control mice were isolated for RNA seq and for comparative gene expression profiling analysis."],"tag":["xref:PubMed:37384529"],"repository":["ENA"],"description_synonyms":["3.4.22.-, Anterior Prefrontal, Brodmann Area 47, Lateral Orbitofrontal, Anterior, Frontal Sulcus, Rectus, Brodmann's Area 47, Medial, Ventromedial, Laboratory, Frontalis Superior, Pars Orbitalis, Mus domesticus, Nerve, Subcallosal Areas, Gene, mini-ICE, CASP-14, House Mouse, Gyrus, Gene Expression Profilings, Transcript Expression Analysis, mRNA Differential Displays, Marginal, Subcallosal, prefrontal association complex, Gene Expression Pattern Analysis, Inferior Frontal Gyrus, House, Lateral Orbitofrontal Cortices, Gene Expression Monitorings, Mus musculus domesticus, Frontal Convolution, Analysis, Profilings, Gyrus Rectus, Olfactory Sulci, Prefrontal Cortices, Pars, Frontal, Ventromedial Prefrontal Cortex, Mice, Convolutions, Gyrus Orbitalis, Anterior Prefrontal Cortices, Brodmanns Area 47, Gyrus Frontalis Superior, Subcallosal Area, Analyses, Orbital Areas, Swiss, Orbital Area, Olfactory Sulcus, Transcriptomics, Swiss Mice, Transcript Expression, Transcriptome Analysis, Orbitofrontal Region, Orbital Gyrus, Monitoring, Gene Expression Analysis, Orbitofrontal Cortex, Glutaminase, Area 47, Superior Frontal Gyrus, Phosphate-Activated, Neuron, Expression Analyses, Orbitofrontal Gyri, Orbital Gyri, Ventral Medial Prefrontal Cortex, Nerve Cell, Straight, Orbitofrontal, Brodmann's, Profiling, Straight Gyrus, Gyrus Frontalis, Rectal, Transcriptome, Anterior Prefrontal Cortex, CASP14, mouse, Monitorings, frontal association cortex, Sulcus, Orbital Cortex, Ventromedial Prefrontal, Cell, Gene Expression, Differential Display, transcription profiling, Brodmann Area 10, Brodmann Area 12, Brodmann Area 11, Transcript Expression Analyses, Cortex, Mus, Brodmann, Superior Frontal Convolution, Mini-ICE, Area, Lateral Orbitofrontal Cortex, Rectal Gyrus, Region, mRNA Differential Display, gene expression profiling, Brodmanns Area 12, Medial Frontal, Brodmanns Area 11, Mus musculus, Gene Expression Monitoring, Brodmanns Area 10, Nerve Cells, Cortices, Gyrus Frontalis Inferior, Transcriptome Profiling, Caspase-14 subunit p10, mRNA, Area 11, Frontal Gyrus, Area 10, Phosphate-Activated Glutaminase, Transcriptome Profilings, Area 12, mice, Superior, Swiss Mouse, Superior Frontal Convolutions, Convolution, House Mice, Caspase-14 subunit p19, Differential Displays, MICE, Nerve., Transcriptome Analyses, Rectus Gyrus, Superior Frontal, Laboratory Mice, domesticus, Orbitofrontal Regions, Prefrontal, Lateral, Marginal Gyrus, Ventromedial Prefrontal Cortices, Brodmann's Area 10, Gene Expression Analyses, Inferior, Brodmann's Area 12, Brodmann's Area 11, Medial Frontal Gyrus, Orbital Cortices, Inferior Frontal, Cells, Prefrontal Cortex, Phosphate Activated Glutaminase, Expression Analysis, Orbitofrontal Cortices, Mouse, L-Glutamine amidohydrolase, Orbitalis, Orbitofrontal Gyrus, Laboratory Mouse, Orbital"],"name_synonyms":["3.4.22.-, Anterior Prefrontal, Brodmann Area 47, Lateral Orbitofrontal, Anterior, Frontal Sulcus, Rectus, Brodmann's Area 47, Medial, Ventromedial, Laboratory, Frontalis Superior, Pars Orbitalis, Mus domesticus, Nerve, Subcallosal Areas, Gene, mini-ICE, CASP-14, House Mouse, Gyrus, Gene Expression Profilings, Transcript Expression Analysis, mRNA Differential Displays, Marginal, Subcallosal, prefrontal association complex, Gene Expression Pattern Analysis, Inferior Frontal Gyrus, House, Lateral Orbitofrontal Cortices, Gene Expression Monitorings, Mus musculus domesticus, Frontal Convolution, Analysis, Profilings, Gyrus Rectus, Olfactory Sulci, Prefrontal Cortices, Pars, Frontal, Ventromedial Prefrontal Cortex, Mice, Convolutions, Gyrus Orbitalis, Anterior Prefrontal Cortices, Brodmanns Area 47, Gyrus Frontalis Superior, Subcallosal Area, Analyses, Orbital Areas, Swiss, Orbital Area, Olfactory Sulcus, Transcriptomics, Swiss Mice, Transcript Expression, Transcriptome Analysis, Orbitofrontal Region, Orbital Gyrus, Monitoring, Gene Expression Analysis, Orbitofrontal Cortex, Glutaminase, Area 47, Superior Frontal Gyrus, Phosphate-Activated, Neuron, Expression Analyses, Orbitofrontal Gyri, Orbital Gyri, Ventral Medial Prefrontal Cortex, Nerve Cell, Straight, Orbitofrontal, Brodmann's, Profiling, Straight Gyrus, Gyrus Frontalis, Rectal, Transcriptome, Anterior Prefrontal Cortex, CASP14, mouse, Monitorings, frontal association cortex, Sulcus, Orbital Cortex, Ventromedial Prefrontal, Cell, Gene Expression, Differential Display, transcription profiling, Brodmann Area 10, Brodmann Area 12, Brodmann Area 11, Transcript Expression Analyses, Cortex, Mus, Brodmann, Superior Frontal Convolution, Mini-ICE, Area, Lateral Orbitofrontal Cortex, Rectal Gyrus, Region, mRNA Differential Display, gene expression profiling, Brodmanns Area 12, Medial Frontal, Brodmanns Area 11, Mus musculus, Gene Expression Monitoring, Brodmanns Area 10, Nerve Cells, Cortices, Gyrus Frontalis Inferior, Transcriptome Profiling, Caspase-14 subunit p10, mRNA, Area 11, Frontal Gyrus, Area 10, Phosphate-Activated Glutaminase, Transcriptome Profilings, Area 12, mice, Superior, Swiss Mouse, Superior Frontal Convolutions, Convolution, House Mice, Caspase-14 subunit p19, Differential Displays, MICE, Nerve., Transcriptome Analyses, Rectus Gyrus, Superior Frontal, Laboratory Mice, domesticus, Orbitofrontal Regions, Prefrontal, Lateral, Marginal Gyrus, Ventromedial Prefrontal Cortices, Brodmann's Area 10, Gene Expression Analyses, Inferior, Brodmann's Area 12, Brodmann's Area 11, Medial Frontal Gyrus, Orbital Cortices, Inferior Frontal, Cells, Prefrontal Cortex, Phosphate Activated Glutaminase, Expression Analysis, Orbitofrontal Cortices, Mouse, L-Glutamine amidohydrolase, Orbitalis, Orbitofrontal Gyrus, Laboratory Mouse, Orbital"],"additional_accession":[]},"is_claimable":false,"name":"Changes in gene expression profiling in the prefrontal cortex from mice lacking glutaminase 1 in CamKIIa-positive neurons","description":"Changes in gene expression profiling in the prefrontal cortex from mice lacking glutaminase 1 in CamKIIa-positive neurons","dates":{"last_updated":"2025-09-24","first_public":"2023-06-03"},"accession":"PRJNA975490","cross_references":{"GEO":["GSE233221"],"taxon":["10090"],"PubMed":["37384529"]}}