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Institute"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA995769"],"scientific_name":["Mus musculus"],"long_description":["We investigated candidate host-directed therapies for tuberculosis in vitro. BMDMs from tuberculosis susceptible mice B6.Sst1S were stimulated with TNF and infected with Mtb. The infected macrophage were treated with Rocaglamide A, ISRIB and JNK inhibitor SP600125 alone or in combinations to asses the inhibitors' effectas on macrophage transcriptome. Overall design: B6.Ssts1S BMDMs were stimulated with 10 ng/ml of TNF for 16h and infected with Mtb H37Rv at MOI=1. At 72h post infection total RNA was isolated and processed for RNA-seq"],"tag":["xref:PubMed:37756395"],"repository":["ENA"],"description_synonyms":["dif, inhibitors, tnfa, TNF-alpha, Transcriptome, Mycobacterium tuberculosis (Zopf 1883) Lehmann and Neumann 1896 (Approved Lists 1980), Transcriptome Profile, Monocyte Derived Macrophages, xtnf, TNF, Expression Profiles, TNFA, Gene Expression Profile, ggr, inhibitor, Gene, Profiles, Monocyte Derived, dt1, whole transcriptome, Gene Expression, tnfsf2, TNF-a, Monocyte-Derived, Expression Signatures, Regg1, Mycobacterium tuberculosis var. hominis, Gene Expression Signatures, Monocyte-Derived Macrophage, tnf-alpha, Gene Expression Signature, Expression Profile, xtnf-alpha, Monocyte-Derived Macrophages, Transcriptome Profiles, Macrophage, antagonists, Bacillus tuberculosis, Bacterium tuberculosis, regg1, Macrophages, Profile, RATTNF, CG12919, inhibiteur, Bone Marrow Derived Macrophages, Bone Marrow-Derived Macrophage, TNFalpha, BcDNA:RH51659, DmelCG12919, Ect1, Signatures, DIF, Bone Marrow-Derived, Mycobacterium tuberculosis H37Rv., darth, inhibidor, antagonists and inhibitors, Expression Signature, Gene Expression Profiles, Bone Marrow-Derived Macrophages, Transcriptomes, TNFSF2, Egr, Tnfa, Signature, Tnfsf1a, Mycobacterium tuberculosis typus humanus"],"name_synonyms":["dif, inhibitors, tnfa, TNF-alpha, Transcriptome, Mycobacterium tuberculosis (Zopf 1883) Lehmann and Neumann 1896 (Approved Lists 1980), Transcriptome Profile, Monocyte Derived Macrophages, xtnf, TNF, Expression Profiles, TNFA, Gene Expression Profile, ggr, inhibitor, Gene, Profiles, Monocyte Derived, dt1, whole transcriptome, Gene Expression, tnfsf2, TNF-a, Monocyte-Derived, Expression Signatures, Regg1, Mycobacterium tuberculosis var. hominis, Gene Expression Signatures, Monocyte-Derived Macrophage, tnf-alpha, Gene Expression Signature, Expression Profile, xtnf-alpha, Monocyte-Derived Macrophages, Transcriptome Profiles, Macrophage, antagonists, Bacillus tuberculosis, Bacterium tuberculosis, regg1, Macrophages, Profile, RATTNF, CG12919, inhibiteur, Bone Marrow Derived Macrophages, Bone Marrow-Derived Macrophage, TNFalpha, BcDNA:RH51659, DmelCG12919, Ect1, Signatures, DIF, Bone Marrow-Derived, Mycobacterium tuberculosis H37Rv., darth, inhibidor, antagonists and inhibitors, Expression Signature, Gene Expression Profiles, Bone Marrow-Derived Macrophages, Transcriptomes, TNFSF2, Egr, Tnfa, Signature, Tnfsf1a, Mycobacterium tuberculosis typus humanus"],"additional_accession":[]},"is_claimable":false,"name":"Effect of small molecule inhibitors on transcriptome of B6.Sst1S bone marrow derived macrophages stimulated with TNF and infected with virulent Mycobacterium tuberculosis","description":"Effect of small molecule inhibitors on transcriptome of B6.Sst1S bone marrow derived macrophages stimulated with TNF and infected with virulent Mycobacterium tuberculosis","dates":{"last_updated":"2025-09-24","first_public":"2023-10-06"},"accession":"PRJNA995769","cross_references":{"GEO":["GSE237582"],"taxon":["10090"],"PubMed":["37756395"]}}