Models,Multiomics

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Puniya2021 - CD4+ Th17 cell metabolism model


ABSTRACT: CD4+ T cells are critical components in the human immune system. They produce cytokines to fight against pathogens and abnormal cells and stimulate other cells, such as B cells, macrophages, and neutrophils, to generate an immune response. T helper 17 (Th17) cells are subtype CD4+ T cells that differentiate from naive CD4+ T cells in a specific cytokine environment. The Th17 cell model consists of 5282 reactions, 3263 metabolites, and 1250 genes. CD4+ T cell models helped identify drug targets and repurposable drugs against autoimmune diseases.

SUBMITTER: Bhanwar Lal Puniya  

PROVIDER: MODEL1909260006 | BioModels | 2023-11-27

REPOSITORIES: BioModels

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Integrative computational approach identifies drug targets in CD4<sup>+</sup> T-cell-mediated immune disorders.

Puniya Bhanwar Lal BL   Amin Rada R   Lichter Bailee B   Moore Robert R   Ciurej Alex A   Bennett Sydney J SJ   Shah Ab Rauf AR   Barberis Matteo M   Helikar Tomáš T  

NPJ systems biology and applications 20210122 1


CD4<sup>+</sup> T cells provide adaptive immunity against pathogens and abnormal cells, and they are also associated with various immune-related diseases. CD4<sup>+</sup> T cells' metabolism is dysregulated in these pathologies and represents an opportunity for drug discovery and development. Genome-scale metabolic modeling offers an opportunity to accelerate drug discovery by providing high-quality information about possible target space in the context of a modeled disease. Here, we develop gen  ...[more]

Publication: 1/596

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