Transcriptomics,Multiomics

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Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies.

ABSTRACT: We comprehensively analyzed clinical, genomic, and transcriptomic data of a cohort of 465 primary triple-negative breast cancer (TNBC). PIK3CA mutations and copy-number gains of chromosome 22q11 were more frequent in our Chinese cohort than in The Cancer Genome Atlas. We classified TNBCs into four transcriptome-based subtypes: (1) luminal androgen receptor (LAR), (2) immunomodulatory, (3) basal-like immune-suppressed, and (4) mesenchymal-like. Putative therapeutic targets or biomarkers were identified among each subtype. Importantly, the LAR subtype showed more ERBB2 somatic mutations, infrequent mutational signature 3 and frequent CDKN2A loss. The comprehensive profile of TNBCs provided here will serve as a reference to further advance the understanding and precision treatment of TNBC.

TISSUE(S): Breast

SUBMITTER: Ding,Ma 

PROVIDER: OEX001582 | NODE |

REPOSITORIES: NODE

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Publications

Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies.

Jiang Yi-Zhou YZ   Ma Ding D   Suo Chen C   Shi Jinxiu J   Xue Mengzhu M   Hu Xin X   Xiao Yi Y   Yu Ke-Da KD   Liu Yi-Rong YR   Liu Yi-Rong YR   Yu Ying Y   Zheng Yuanting Y   Li Xiangnan X   Zhang Chenhui C   Hu Pengchen P   Zhang Jing J   Hua Qi Q   Zhang Jiyang J   Hou Wanwan W   Ren Luyao L   Bao Ding D   Li Bingying B   Yang Jingcheng J   Yao Ling L   Zuo Wen-Jia WJ   Zhao Shen S   Gong Yue Y   Ren Yi-Xing YX   Zhao Ya-Xin YX   Yang Yun-Song YS   Niu Zhenmin Z   Cao Zhi-Gang ZG   Stover Daniel G DG   Verschraegen Claire C   Kaklamani Virginia V   Daemen Anneleen A   Benson John R JR   Takabe Kazuaki K   Bai Fan F   Li Da-Qiang DQ   Wang Peng P   Shi Leming L   Huang Wei W   Shao Zhi-Ming ZM  

Cancer cell 20190307 3

We comprehensively analyzed clinical, genomic, and transcriptomic data of a cohort of 465 primary triple-negative breast cancer (TNBC). PIK3CA mutations and copy-number gains of chromosome 22q11 were more frequent in our Chinese cohort than in The Cancer Genome Atlas. We classified TNBCs into four transcriptome-based subtypes: (1) luminal androgen receptor (LAR), (2) immunomodulatory, (3) basal-like immune-suppressed, and (4) mesenchymal-like. Putative therapeutic targets or biomarkers were iden  ...[more]

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