Comparison of control and Elmod1 knockout utricle extracts using tandem mass tagging
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Utricle
SUBMITTER: 
Peter Barr-Gillespie
LAB HEAD: Peter Barr-Gillespie
PROVIDER: PXD006164 | Pride | 2018-10-24
REPOSITORIES: Pride
Publications
ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells.
Krey Jocelyn F JF Dumont Rachel A RA Wilmarth Philip A PA David Larry L LL Johnson Kenneth R KR Barr-Gillespie Peter G PG
The Journal of neuroscience : the official journal of the Society for Neuroscience 20171208 4
Sensory hair cells require control of physical properties of their apical plasma membranes for normal development and function. Members of the ADP-ribosylation factor (ARF) small GTPase family regulate membrane trafficking and cytoskeletal assembly in many cells. We identified ELMO domain-containing protein 1 (ELMOD1), a guanine nucleoside triphosphatase activating protein (GAP) for ARF6, as the most highly enriched ARF regulator in hair cells. To characterize ELMOD1 control of trafficking, we a ...[more]
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