Proteomic analysis of human alveolar bone
Ontology highlight
ABSTRACT:
INSTRUMENT(S): impact II
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Bone
SUBMITTER: 
Peter Bell
LAB HEAD: Christopher M Overall
PROVIDER: PXD011524 | Pride | 2019-11-27
REPOSITORIES: Pride
Publications
Proteomic and N-Terminomic TAILS Analyses of Human Alveolar Bone Proteins: Improved Protein Extraction Methodology and LysargiNase Digestion Strategies Increase Proteome Coverage and Missing Protein Identification.
Bell Peter A PA Solis Nestor N Kizhakkedathu Jayachandran N JN Matthew Ian I Overall Christopher M CM
Journal of proteome research 20191025 12
With 2129 proteins still classified by the Human Proteome Organisation Human Proteome Project (HPP) as "missing" without compelling evidence of protein existence (PE) in humans, we hypothesized that in-depth proteomic characterization of tissues that are technically challenging to access and extract would yield evidence for tissue-specific missing proteins. Paradoxically, although the skeleton is the most massive tissue system in humans, as one of the poorest characterized by proteomics, bone fa ...[more]
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